iPTMnet Report for Q9BQ52 (ELAC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BQ52 / RNZ2_HUMAN
Protein Name Zinc phosphodiesterase ELAC protein 2 precursor
Gene Name Name: ELAC2
Synonyms:HPC2;
Organism Homo sapiens (Human)

PRO ID PR:Q9BQ52
DAG View
PRO Name zinc phosphodiesterase ELAC protein 2 (human)
Definition A zinc phosphodiesterase ELAC protein 2 that is encoded in the genome of human.
Short Label hELAC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BQ52 (ELAC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34019948, 35083852, 28510447
R14 Methylation PhosphoSitePlus
R28 Methylation PhosphoSitePlus
K99 Methylation PhosphoSitePlus
K101 Methylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
C136 Methylation IEDB 31844290
K146 Ubiquitination PhosphoSitePlus
K152 Acetylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
S199 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S205 Phosphorylation PhosphoSitePlus
S208 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S212 Phosphorylation PhosphoSitePlus   UniProt 24275569
S213 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S215 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus   UniProt 23186163
S238 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K279 Acetylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
C421 Methylation IEDB 31844290
K424 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
C609 Methylation IEDB 31844290
S618 Phosphorylation PhosphoSitePlus   UniProt 23186163
C670 Methylation IEDB 31844290
K678 Ubiquitination PhosphoSitePlus
T688 Phosphorylation PhosphoSitePlus
T701 Phosphorylation PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus   UniProt 23186163
S740 Phosphorylation PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus
C753 Methylation IEDB 31844290
K762 Acetylation IEDB 34357683
K762 Ubiquitination PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
T815 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S199 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
S205 Phosphorylation HPRD 19651622, 20068231
S208 Phosphorylation HPRD 19651622, 18669648, 20068231
S212 Phosphorylation HPRD 19651622
S213 Phosphorylation HPRD 19651622, 18669648, 20068231
S215 Phosphorylation HPRD 19651622
S229 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S208 R208 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S217 L217 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S229 N229 Biomuta DOID:3571 / liver cancer [ cosmic ]
T701 K701 Biomuta DOID:3571 / liver cancer [ cosmic ]
K762 T762 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]