iPTMnet Report Q99879 H2BC14

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q99879 / H2B1M_HUMAN
Protein Name	Histone H2B type 1-M
Gene Name	Name: H2BC14 Synonyms:H2BFE;
Organism	Homo sapiens (Human)

PRO ID	PR:Q99879 DAG View
PRO Name	histone H2B type 1-M (human)
Definition	A histone H2B type 1-M that is encoded in the genome of human.
Short Label	hH2BC14
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q99879 (H2BC14) as Substrate

Q99879

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
		Acetylation		score1	PRO
	M1	Acetylation		score1	PRO
	K6	Acetylation		score2	PRO UniProt	18552846, 19608861, 16283522
	K12	Acetylation		score1	PhosphoSitePlus
	K13	Acetylation		score2	PRO UniProt	18552846, 19608861, 20693536, ...16283522
	S15	Phosphorylation		score2	PRO UniProt	12757711
	K16	Acetylation		score2	PRO PhosphoSitePlus UniProt	19608861, 19883641, 16283522
	K17	Acetylation		score2	PRO UniProt	19608861, 20693536
	K21	Acetylation		score2	PRO UniProt	18552846, 19608861, 16283522
	K24	Acetylation		score2	PhosphoSitePlus UniProt	19608861
	K35	Ubiquitination		score1	UniProt	21726816
	K47	Acetylation		score1	PRO	20693536
	S56	Phosphorylation		score1	PhosphoSitePlus
	K121	Acetylation		score1	PRO	18552846
	K121	Ubiquitination		score2	PRO UniProt	18400894, 16307923, 19575011, ...16713563, 18923072, 18832071

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000036260 (hHIST1H2BM/Ac:1)	acM1		PRO
	PR:000045101 (hHIST1H2BM/InitMet-/Ac:1)	acK13		PRO	16283522, 18552846, 20693536
	PR:000045102 (hHIST1H2BM/InitMet-/Phos:1)	pS15		PRO	12757711
	PR:000045103 (hHIST1H2BM/InitMet-/Ac:2)	acK21		PRO	16283522, 18552846
	PR:000045105 (hHIST1H2BM/InitMet-/Ubiq:1)	ubK121		PRO	16307923, 16713563, 18400894, ...18832071, 18923072, 19575011
	PR:000045106 (hHIST1H2BM/InitMet-/Ac:3)	acK17		PRO	20693536
	PR:000045107 (hHIST1H2BM/InitMet-/Ac:4)	acK6		PRO	18552846
	PR:000045109 (hHIST1H2BM/InitMet-/Ac:5)	acK47		PRO	20693536
	PR:000045110 (hHIST1H2BM/InitMet-/Ac:6)	acK121		PRO	18552846
	PR:000045111 (hHIST1H2BM/InitMet-/Ac:7)	acK16		PRO	19883641
	PR:000047808 (hHIST1H2BM/InitMet-/N6AcLys+)	ac		PRO

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S15	C15	Biomuta		DOID:3571 / liver cancer [ cosmic ]
K24	*	Biomuta		DOID:1324 / lung cancer [ cosmic ]
S56	F56	Biomuta		DOID:4362 / cervical cancer [ cosmic ]