Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99708 / CTIP_HUMAN
Protein Name DNA endonuclease RBBP8
Gene Name Name: RBBP8
Synonyms:CTIP;
Organism Homo sapiens (Human)

PRO ID PR:Q99708
DAG View
PRO Name DNA endonuclease RBBP8 (human)
Definition A DNA endonuclease RBBP8 that is encoded in the genome of human.
Short Label hRBBP8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99708 (RBBP8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation RLIMS-P 25267294
S10 Phosphorylation PhosphoSitePlus   RLIMS-P 23468639
S17 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K115 Sumoylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus   RLIMS-P 23468639
S231 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23468639, 23186163
T245 Phosphorylation PhosphoSitePlus   RLIMS-P 23468639
S276 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23468639, 23623683
K314 Ubiquitination PhosphoSitePlus
T315 Phosphorylation P24941 (CDK2) PhosphoSitePlus   RLIMS-P   UniProt 23468639, 23186163, 23623683
T323 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus   UniProt 17965729
S327 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 21087997, 23186163, 21893598, ...15302935, 19357644, 23468639, 28132842, 25267294, 15485915, 24837676, 24196441
S345 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus   RLIMS-P 23468639
S349 Phosphorylation PhosphoSitePlus   UniProt 17965729
T361 Phosphorylation PhosphoSitePlus
K378 Sumoylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus   UniProt 23186163
T422 Phosphorylation PhosphoSitePlus
Y424 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
K432 Acetylation PRO   PhosphoSitePlus   UniProt 20829486
K438 Sumoylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
K449 Sumoylation PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
K513 Acetylation PhosphoSitePlus
K515 Acetylation PhosphoSitePlus
Y522 Phosphorylation PhosphoSitePlus
K526 Acetylation PRO   PhosphoSitePlus   UniProt 20829486
K526 Ubiquitination PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus   RLIMS-P 23468639
S555 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus   RLIMS-P 23468639
K578 Sumoylation PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
K604 Acetylation PRO   PhosphoSitePlus   UniProt 20829486
K604 Sumoylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
S664 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25267294, 10910365
S679 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 17965729
S723 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S745 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25267294, 10910365
K774 Sumoylation PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus
T847 Phosphorylation P06493 (CDK1) , P24941 (CDK2) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19202191, 23468639, 25267294, ...27889449, 23144634, 24837676
T859 Phosphorylation Q13535 (ATR) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor 23468639, 23273981
K869 Sumoylation PhosphoSitePlus
S889 Phosphorylation RLIMS-P 23468639
Site PTM Type PTM Enzyme Score Source PMID
S326 Phosphorylation HPRD 19664995
S327 Phosphorylation HPRD 17322306, 19664995, 20068231
S664 Phosphorylation Q13315 (ATM) HPRD 11689934, 10910365
S679 Phosphorylation HPRD 17525332
S723 Phosphorylation HPRD 20068231, 18452278
S745 Phosphorylation Q13315 (ATM) HPRD 11689934, 10910365
S836 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
S326 Phosphorylation HPRD 19664995
S327 Phosphorylation HPRD 17322306, 19664995, 20068231
S664 Phosphorylation Q13315 (ATM) HPRD 11689934, 10910365
S679 Phosphorylation HPRD 17525332
S723 Phosphorylation HPRD 20068231, 18452278
S745 Phosphorylation Q13315 (ATM) HPRD 11689934, 10910365


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049021 (hRBBP8/Ac:1) acK432,acK526,acK604 PRO
PR:000049022 (hRBBP8/Phos:1) pS327,pT847 PRO
PR:000049023 (hRBBP8/Phos:2) pS327,pT847,pT859 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q99708 (RBBP8) S327 P38398 (BRCA1) unknown eFIP 23468639
Phosphorylation Q99708 (RBBP8) S327 P38398 (BRCA1) unknown eFIP 24832651
Phosphorylation Q99708 (RBBP8) S327 P38398 (BRCA1) unknown eFIP 28132842
Phosphorylation Q99708 (RBBP8) S745 P38398 (BRCA1) unknown eFIP 24832651
Phosphorylation Q99708 (RBBP8) S664 P38398 (BRCA1) unknown eFIP 24832651
Phosphorylation Q99708 (RBBP8) S327 P48754 (Brca1) unknown eFIP 22231403