iPTMnet Report for Q99697 (PITX2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99697 / PITX2_HUMAN
Protein Name Pituitary homeobox 2
Gene Name Name: PITX2
Synonyms:ARP1,RGS,RIEG,RIEG1;
Organism Homo sapiens (Human)

PRO ID PR:Q99697
DAG View
PRO Name pituitary homeobox 2 (human)
Definition A pituitary homeobox 2 that is encoded in the genome of human.
Short Label hPITX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99697 (PITX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation PhosphoSitePlus
T90 Phosphorylation P31749 (AKT1) , P31751 (AKT2) neXtProt 20019746
S283 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T58 Phosphorylation HPRD   PhosphoSitePlus 17081983
S60 Phosphorylation HPRD   PhosphoSitePlus 17081983
T62 Phosphorylation HPRD 17081983
S63 Phosphorylation HPRD   PhosphoSitePlus 17081983
S64 Phosphorylation HPRD   PhosphoSitePlus 17081983
Site PTM Type PTM Enzyme Score Source PMID
K19 Acetylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036294 (hPITX2/iso:4) Interaction PR:Q99697-2 (hPITX2/iso:Ptx2C) PRO 11948188
PR:000036294 (hPITX2/iso:4) Interaction PR:Q99697-3 (hPITX2/iso:Ptx2A) PRO 11948188
PR:Q99697-1 (hPITX2/iso:Ptx2B) Interaction PR:Q99697-3 (hPITX2/iso:Ptx2A) PRO 11948188
PR:Q99697-1 (hPITX2/iso:Ptx2B) Interaction PR:Q99697-2 (hPITX2/iso:Ptx2C) PRO 11948188
PR:Q99697-2 (hPITX2/iso:Ptx2C) Interaction PR:Q99697-3 (hPITX2/iso:Ptx2A) PRO 11948188
PR:Q99697-2 (hPITX2/iso:Ptx2C) Interaction PR:Q99697-1 (hPITX2/iso:Ptx2B) PRO 11948188
PR:Q99697-3 (hPITX2/iso:Ptx2A) Interaction PR:Q99697-2 (hPITX2/iso:Ptx2C) PRO 11948188


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T58 I58 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S60 T60 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S64 R64 Biomuta DOID:10534 / stomach cancer [ cosmic ]