iPTMnet Report Q99683 MAP3K5

Protein Information

UniProt AC / UniProt ID	Q99683 / M3K5_HUMAN
Protein Name	Mitogen-activated protein kinase kinase kinase 5
Gene Name	Name: MAP3K5 Synonyms:ASK1,MAPKKK5,MEKK5;
Organism	Homo sapiens (Human)

PRO ID	PR:Q99683 DAG View
PRO Name	mitogen-activated protein kinase kinase kinase 5 (human)
Definition	A mitogen-activated protein kinase kinase kinase 5 that is encoded in the genome of human.
Short Label	hMAP3K5
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q99683 (MAP3K5) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
R78	Methylation		score2	UniProt	22095282
R80	Methylation		score2	UniProt	22095282
S82	Phosphorylation		score1	PhosphoSitePlus
S83	Phosphorylation	P11309 (PIM1) , P51812 (RPS6KA3) , P31749 (AKT1) , P31751 (AKT2)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P+ RLIMS-P Signor UniProt	26661061, 26912789, 32111229, ...25982447, 12697749, 20112989, 16098218, 14500571, 22194952, 23608533, 15782121, 16532036, 19749799, 11154276, 23476679, 15242986, 15911620
R89	Methylation		score1	PhosphoSitePlus
S101	Phosphorylation		score1	PhosphoSitePlus
S115	Phosphorylation		score1	PhosphoSitePlus
C120	Methylation		score1	IEDB	31844290
S461	Phosphorylation		score1	PhosphoSitePlus
K465	Ubiquitination		score1	PhosphoSitePlus
T528	Phosphorylation		score1	PhosphoSitePlus
K535	Sumoylation		score1	PhosphoSitePlus
Y570	Phosphorylation		score1	PhosphoSitePlus
Y574	Phosphorylation		score1	PhosphoSitePlus
K709	Ubiquitination		score1	PhosphoSitePlus
Y718	Phosphorylation	O60674 (JAK2) , P23458 (JAK1)	score4	IntAct neXtProt PhosphoSitePlus Signor UniProt	16407264, 19287004
K730	Ubiquitination		score1	PhosphoSitePlus
K785	Ubiquitination		score1	PhosphoSitePlus
T813	Phosphorylation	Q99683 (MAP3K5)	score3	neXtProt PhosphoSitePlus RLIMS-P Signor UniProt	17937911
Y814	Phosphorylation		score1	PhosphoSitePlus
S821	Phosphorylation		score1	PhosphoSitePlus
T825	Phosphorylation		score1	PhosphoSitePlus
K827	Ubiquitination		score1	PhosphoSitePlus
T838	Phosphorylation	Q14680 (MELK) , Q99683 (MAP3K5) , O95382 (MAP3K6) , Q15139 (PRKD1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	28600984, 19590015, 23102700, ...20112989, 19805025, 9564042, 17937911, 11920685, 19570911, 31926625, 19935702, 15755722, 19920149, 17210579, 18948261
T842	Phosphorylation	Q99683 (MAP3K5)	score4	neXtProt PhosphoSitePlus RLIMS-P Signor UniProt	17937911, 11920685
C869	S-Nitrosylation		score2	dbSNO	22178444, 14668338, 15688001
K946	Acetylation		score1	PhosphoSitePlus
S958	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S964	Phosphorylation		score1	PhosphoSitePlus
S966	Phosphorylation	O15530 (PDPK1) , Q99683 (MAP3K5)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	22276160, 15094778, 16648474, ...26095851, 14688258, 19590015, 19920149, 10411906
Y982	Phosphorylation		score1	PhosphoSitePlus
S986	Phosphorylation		score1	PhosphoSitePlus
S997	Phosphorylation		score1	PhosphoSitePlus
S1029	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 18088087
S1033	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	19369195, 18088087, 15094778, ...18669648, 19590015
T1059	Phosphorylation		score1	PhosphoSitePlus
K1064	Ubiquitination		score1	PhosphoSitePlus
K1083	Sumoylation		score1	PhosphoSitePlus
T1109	Phosphorylation	P51812 (RPS6KA3)	score3	PhosphoSitePlus RLIMS-P	23608533
K1114	Sumoylation		score1	PhosphoSitePlus
S1234	Phosphorylation		score1	IEDB	32897882
S1240	Phosphorylation		score1	PhosphoSitePlus
T1326	Phosphorylation	P51812 (RPS6KA3)	score3	PhosphoSitePlus RLIMS-P	23608533

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S83	Phosphorylation	P31749 (AKT1)	score1	HPRD	11154276
T838	Phosphorylation	Q99683 (MAP3K5)	score1	HPRD	11920685
T842	Phosphorylation		score1	HPRD	11920685
S966	Phosphorylation		score1	HPRD	10411906
S1029	Phosphorylation		score0	HPRD	18691976, 18669648, 18088087
S1033	Phosphorylation		score0	HPRD	18669648, 18088087

Q99683 (MAP3K5) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O15530 (PDPK1)	S394	score4	neXtProt PhosphoSitePlus	19920149, 22544756
O15530 (PDPK1)	S398	score4	neXtProt PhosphoSitePlus	19920149, 22544756
P38936 (CDKN1A)	S98	score3	phospho.ELM PhosphoSitePlus Signor	17325029
P45379-11 (TNNT2)	T191	score1	HPRD	12819028
P45379-6 (TNNT2)	T194	score1	HPRD	12819028
P45379-11 (TNNT2)	S195	score1	HPRD	12819028
P45379-6 (TNNT2)	S198	score1	HPRD	12819028
P45379-10 (TNNT2)	T201	score1	HPRD	12819028
P45379 (TNNT2)	T204	score2	neXtProt	12819028
P45379-10 (TNNT2)	S205	score1	HPRD	12819028
P45379 (TNNT2)	S208	score2	neXtProt	12819028
P45983 (MAPK8)	T183	score2	PhosphoSitePlus	19749799
P45983 (MAPK8)	Y185	score2	PhosphoSitePlus	19749799
P45985 (MAP2K4)	T261	score4	phospho.ELM PhosphoSitePlus Signor	8974401, 15911620
P46734 (MAP2K3)	S218	score3	PhosphoSitePlus Signor	19920149
P52564 (MAP2K6)	S207	score2	PhosphoSitePlus	19920149
Q16539 (MAPK14)	T180	score2	PhosphoSitePlus	19749799
Q16539 (MAPK14)	Y182	score2	PhosphoSitePlus	19749799
Q969S3 (ZNF622)	S314	score3	neXtProt PhosphoSitePlus Signor	21771788
Q969S3 (ZNF622)	T318	score3	neXtProt PhosphoSitePlus Signor	21771788
Q99683 (MAP3K5)	T813	score3	neXtProt PhosphoSitePlus Signor UniProt	17937911
Q99683 (MAP3K5)	T838	score4	HPRD neXtProt PhosphoSitePlus Signor UniProt	9564042, 17937911, 19920149, ...11920685
Q99683 (MAP3K5)	T842	score3	neXtProt PhosphoSitePlus Signor UniProt	17937911
Q99683 (MAP3K5)	S966	score4	phospho.ELM PhosphoSitePlus UniProt	19920149, 14688258, 10411906, ...16648474
Q9UER7 (DAXX)	S176	score4	PhosphoSitePlus Signor	19789334, 19789335
Q9UER7 (DAXX)	S184	score4	PhosphoSitePlus Signor	19789334, 19789335
Q9Y3F4 (STRAP)	T175	score2	PhosphoSitePlus	19880523
Q9Y3F4 (STRAP)	S179	score2	PhosphoSitePlus	19880523

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	Q99683 (MAP3K5)	S83	P11309 (PIM1)	unknown	eFIP	19749799
	Phosphorylation	Q99683 (MAP3K5)	S83	P31749 (AKT1)	decreased_association	eFIP	26912789

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
R89	L89	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S101	N101	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
S115	N115	Biomuta	DOID:363 / uterine cancer [ icgc ]
S461	G461	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y570	D570	Biomuta	DOID:363 / uterine cancer [ icgc ]
Y574	F574	Biomuta	DOID:1612 / breast cancer [ cosmic ]
K730	*	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T813	I813	Biomuta	DOID:5041 / esophageal cancer [ cosmic, icgc ]
T813	A813	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S966	F966	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
Y982	H982	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S986	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S986	L986	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T1059	M1059	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ]
S1240	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q99683 (MAP3K5)

Protein Information

Interactive Sequence View

Q99683 (MAP3K5) as Substrate

Q99683 (MAP3K5) as PTM Enzyme

PTM-dependent PPI

PTM sites affected in variants