iPTMnet Report for Q99590 (SCAF11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99590 / SCAFB_HUMAN
Protein Name Protein SCAF11
Gene Name Name: SCAF11
Synonyms:CASP11,SFRS2IP,SIP1,SRSF2IP;
Organism Homo sapiens (Human)

PRO ID PR:Q99590
DAG View
PRO Name protein SCAF11 (human)
Definition A protein SCAF11 that is encoded in the genome of human.
Short Label hSCAF11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99590 (SCAF11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Sumoylation PhosphoSitePlus
T5 Phosphorylation PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
C59 Methylation IEDB 31844290
S77 Phosphorylation phospho.ELM 18669648
K83 Sumoylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K113 Sumoylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
C148 Methylation IEDB 31844290
K151 Ubiquitination PhosphoSitePlus
S160 Phosphorylation phospho.ELM 15302935
K165 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S218 Phosphorylation phospho.ELM 17525332, 15302935, 18669648
K285 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
R308 Methylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus   UniProt 23186163
S333 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus   UniProt 18669648
S341 Phosphorylation PhosphoSitePlus   UniProt 18669648
S344 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
S344 Phosphorylation PhosphoSitePlus   UniProt 18669648
C346 S-Nitrosylation dbSNO 26338901
S357 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
S376 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus   UniProt 21406692
S401 Phosphorylation PhosphoSitePlus   UniProt 21406692
S402 Phosphorylation PhosphoSitePlus   UniProt 21406692
S405 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332, 20068231
T410 Phosphorylation PhosphoSitePlus   UniProt 18669648
S413 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S416 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
C446 Methylation IEDB 31844290
S449 Phosphorylation PhosphoSitePlus
C450 S-Nitrosylation dbSNO 26338901
S473 Phosphorylation PhosphoSitePlus
S512 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
S512 Phosphorylation phospho.ELM 17081983
K525 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S535 Phosphorylation PhosphoSitePlus
C542 Methylation IEDB 31844290
C553 Methylation IEDB 31844290
S565 Phosphorylation phospho.ELM 17287340
S588 Phosphorylation PhosphoSitePlus   UniProt 23186163
K596 Ubiquitination PhosphoSitePlus
K601 Sumoylation PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...24275569, 19690332, 20068231
K610 Sumoylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S626 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
K676 Sumoylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
S680 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
S680 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K684 Ubiquitination PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S694 Phosphorylation PhosphoSitePlus   UniProt 23186163
S710 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus   UniProt 17081983
S726 Phosphorylation PhosphoSitePlus   UniProt 17081983
S731 Phosphorylation PhosphoSitePlus
T769 Phosphorylation PhosphoSitePlus   UniProt 21406692
S771 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S774 Phosphorylation PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
T780 Phosphorylation PhosphoSitePlus
T784 Phosphorylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
S796 Phosphorylation IEDB   PhosphoSitePlus   UniProt 21406692, 23186163, 19690332, ...18669648, 24275569, 29493099, 20068231
S798 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
T799 Phosphorylation PhosphoSitePlus
T800 Phosphorylation PhosphoSitePlus
S802 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 19690332
T807 Phosphorylation PhosphoSitePlus   UniProt 18669648
K812 Methylation PhosphoSitePlus
S816 Phosphorylation PhosphoSitePlus   UniProt 24275569
S818 Phosphorylation PhosphoSitePlus
K825 Acetylation PhosphoSitePlus
S830 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
S862 Phosphorylation PhosphoSitePlus
S864 Phosphorylation PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
S875 Phosphorylation PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
S880 Phosphorylation PhosphoSitePlus
S882 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
S882 Phosphorylation PhosphoSitePlus
T887 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
S902 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
S909 Phosphorylation PhosphoSitePlus
S911 Phosphorylation PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
S953 Phosphorylation PhosphoSitePlus
R956 Methylation PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
Y962 Phosphorylation PhosphoSitePlus
S963 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
R965 Methylation PhosphoSitePlus
R969 Methylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
K1027 Ubiquitination PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus
K1043 Ubiquitination PhosphoSitePlus
S1058 Phosphorylation PhosphoSitePlus
K1090 Methylation PhosphoSitePlus
K1090 Ubiquitination PhosphoSitePlus
R1096 Methylation PhosphoSitePlus
K1101 Ubiquitination PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
S1107 Phosphorylation PhosphoSitePlus
S1109 Phosphorylation PhosphoSitePlus
S1122 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1124 Methylation PhosphoSitePlus
K1124 Ubiquitination PhosphoSitePlus
K1126 Ubiquitination PhosphoSitePlus
S1127 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   UniProt 18669648, 21851590, 23186163, ...20068231
S1132 Phosphorylation PhosphoSitePlus
T1135 Phosphorylation PhosphoSitePlus
R1139 Methylation PhosphoSitePlus
S1140 Phosphorylation PhosphoSitePlus
R1151 Methylation PhosphoSitePlus   UniProt 24129315
K1152 Ubiquitination PhosphoSitePlus
T1153 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1161 Phosphorylation PhosphoSitePlus
Y1162 Phosphorylation PhosphoSitePlus
R1164 Methylation PhosphoSitePlus
R1165 Methylation PhosphoSitePlus
R1167 Methylation PhosphoSitePlus
S1169 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1170 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1174 Phosphorylation PhosphoSitePlus
K1178 Sumoylation PhosphoSitePlus
K1178 Ubiquitination PhosphoSitePlus
T1259 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
T1268 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
T1270 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
S1271 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
S1273 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
S1286 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
S1337 Phosphorylation PhosphoSitePlus
S1344 Phosphorylation PhosphoSitePlus
S1349 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948
K1354 Acetylation PhosphoSitePlus
K1354 Ubiquitination PhosphoSitePlus
S1370 Phosphorylation PhosphoSitePlus
K1392 Acetylation PhosphoSitePlus
Y1395 Phosphorylation PhosphoSitePlus
K1439 Acetylation PhosphoSitePlus
K1445 Acetylation PhosphoSitePlus
K1450 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T317 Phosphorylation HPRD 19664995
T331 Phosphorylation HPRD 18452278
S333 Phosphorylation HPRD 18669648
S335 Phosphorylation HPRD 20068231
S338 Phosphorylation HPRD 18669648, 15302935, 18452278
S341 Phosphorylation HPRD 18669648, 17081983
S344 Phosphorylation HPRD 18669648
S364 Phosphorylation HPRD 17081983
S392 Phosphorylation HPRD 18669648
S400 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S401 Phosphorylation HPRD 18669648, 17081983, 18452278
S402 Phosphorylation HPRD 18669648, 15302935, 18452278
S405 Phosphorylation HPRD 19413330, 15302935, 18452278, ...19651622, 18669648, 20068231
T410 Phosphorylation HPRD 19651622, 18669648, 18452278
S413 Phosphorylation HPRD 19651622, 18669648, 15302935, ...18452278
S416 Phosphorylation HPRD 15302935
S533 Phosphorylation HPRD 18077418, 15302935, 18669648, ...20068231, 18452278
S587 Phosphorylation HPRD 20068231
S588 Phosphorylation HPRD 20068231
T602 Phosphorylation HPRD 17081983
S608 Phosphorylation HPRD 19413330, 17322306, 19664994, ...18452278, 19651622, 18669648, 20166139, 20068231
S613 Phosphorylation HPRD 18669648, 17081983, 18452278
S614 Phosphorylation HPRD 19413330, 15302935, 18452278, ...19651622, 18669648, 20068231
S680 Phosphorylation HPRD 18669648, 20068231, 18452278
S687 Phosphorylation HPRD 19651622, 20068231
S694 Phosphorylation HPRD 20068231
T695 Phosphorylation HPRD 20068231
S723 Phosphorylation HPRD 18669648, 17081983
S726 Phosphorylation HPRD 18669648, 17081983, 18452278
S731 Phosphorylation HPRD 18669648
T769 Phosphorylation HPRD 17081983
S771 Phosphorylation HPRD 19413330, 19651622, 20068231
S774 Phosphorylation HPRD 17322306, 18767875, 19651622, ...20068231, 18452278
S776 Phosphorylation HPRD 19413330, 17322306, 18767875, ...19664994, 18452278, 19651622, 20068231
T780 Phosphorylation HPRD 19651622, 17081983
S796 Phosphorylation HPRD 17322306, 18452278, 19651622, ...18669648, 18707149, 20068231
S798 Phosphorylation HPRD 20230923
T799 Phosphorylation HPRD 18669648, 17081983, 20068231, ...20230923
T800 Phosphorylation HPRD 18669648, 17081983, 20230923
S802 Phosphorylation HPRD 17322306, 20230923, 18452278, ...19651622, 18669648, 20068231
T807 Phosphorylation HPRD 18669648
S816 Phosphorylation HPRD 17287340, 17081983, 20068231
S818 Phosphorylation HPRD 17287340, 17081983, 20068231
S827 Phosphorylation HPRD 17081983
S832 Phosphorylation HPRD 17081983
S875 Phosphorylation HPRD 20068231
S878 Phosphorylation HPRD 19651622, 17287340, 20068231
S880 Phosphorylation HPRD 19651622, 17287340, 20068231
S882 Phosphorylation HPRD 19651622, 17287340, 20068231
S902 Phosphorylation HPRD 20068231
S937 Phosphorylation HPRD 19651622
S939 Phosphorylation HPRD 19651622
S941 Phosphorylation HPRD 19651622
S953 Phosphorylation HPRD 18669648
S961 Phosphorylation HPRD 20068231
Y962 Phosphorylation HPRD 18669648, 20068231
S963 Phosphorylation HPRD 18669648, 17081983, 20068231
S1012 Phosphorylation HPRD 20068231
S1109 Phosphorylation HPRD 19413330
S1127 Phosphorylation HPRD 18669648, 20068231
S1169 Phosphorylation HPRD 20068231
S1170 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S77 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S128 C128 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S130 R130 Biomuta DOID:4362 / cervical cancer [ icgc ]
K135 N135 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S160 R160 Biomuta DOID:4159 / skin cancer [ cosmic ]
K165 E165 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T318 A318 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S344 F344 Biomuta DOID:10283 / prostate cancer [ cosmic ]
C346 S346 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S473 L473 Biomuta [ cosmic ]
S533 L533 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T602 R602 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K610 E610 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S614 F614 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K676 T676 Biomuta DOID:363 / uterine cancer [ icgc ]
S680 Y680 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S731 C731 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S776 G776 Biomuta DOID:263 / kidney cancer [ cosmic ]
S792 F792 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S798 F798 Biomuta DOID:4159 / skin cancer [ cosmic ]
T807 A807 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
K825 E825 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S832 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S846 F846 Biomuta DOID:4159 / skin cancer [ cosmic ]
S850 F850 Biomuta [ cosmic ]
S864 C864 Biomuta DOID:1612 / breast cancer [ cosmic ]
S866 P866 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T887 A887 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S902 F902 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S907 F907 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S911 I911 Biomuta DOID:363 / uterine cancer [ icgc ]
S937 C937 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S937 Y937 Biomuta DOID:3571 / liver cancer [ cosmic ]
S953 P953 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R965 P965 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R965 W965 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K1027 Q1027 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1058 Y1058 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1096 W1096 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1104 L1104 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S1122 F1122 Biomuta [ cosmic ]
S1132 L1132 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1139 I1139 Biomuta DOID:363 / uterine cancer [ icgc ]
K1152 E1152 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1152 N1152 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1161 C1161 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
R1164 Q1164 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1165 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1169 Y1169 Biomuta DOID:363 / uterine cancer [ icgc ]
S1170 L1170 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1174 Y1174 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1271 N1271 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1286 P1286 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1344 R1344 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1450 N1450 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]