iPTMnet Report for Q99497 (PARK7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99497 / PARK7_HUMAN
Protein Name Parkinson disease protein 7 precursor
Gene Name Name: PARK7
Organism Homo sapiens (Human)

PRO ID PR:Q99497
DAG View
PRO Name parkinson disease protein 7 (human)
Definition A parkinson disease protein 7 that is encoded in the genome of human.
Short Label hPARK7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99497 (PARK7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 25944712
T19 Phosphorylation PhosphoSitePlus
R27 Methylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
C46 S-Nitrosylation dbSNO 26338901, 24105792
S47 Phosphorylation PhosphoSitePlus
C53 S-Nitrosylation dbSNO 19483679, 26338901
S57 Phosphorylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
Y67 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
K89 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus   RLIMS-P 32858971
K130 Acetylation PhosphoSitePlus
K130 Sumoylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
S142 Phosphorylation HPRD 20068231
K148 Acetylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T19 M19 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T19 A19 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R27 G27 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S47 R47 Biomuta DOID:4159 / skin cancer [ cosmic ]
K99 R99 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T154 I154 Biomuta DOID:1612 / breast cancer [ cosmic ]
K175 T175 Biomuta DOID:2531 / hematologic cancer [ cosmic ]