iPTMnet Report for Q99081 (TCF12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99081 / HTF4_HUMAN
Protein Name Transcription factor 12
Gene Name Name: TCF12
Synonyms:BHLHB20,HEB,HTF4;
Organism Homo sapiens (Human)

PRO ID PR:Q99081
DAG View
PRO Name transcription factor 12 (human)
Definition A transcription factor 12 that is encoded in the genome of human.
Short Label hTCF12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99081 (TCF12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
T40 O-Glycosylation GlyGen 33214551, 34019948, 29351928, ...35132862, 31492838, 35254053
S43 Phosphorylation PhosphoSitePlus
S44 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S47 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S49 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S59 Phosphorylation PhosphoSitePlus
T62 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S72 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus   UniProt 23186163
T100 Phosphorylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
R114 Methylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y120 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S192 O-Glycosylation GlyGen 33214551, 34019948, 29351928, ...35132862, 31492838, 35254053
S198 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S281 O-Glycosylation GlyGen 33214551, 34019948, 35254053, ...35132862, 31492838, 29351928, 29237092
S283 O-Glycosylation GlyGen 33214551, 34019948, 29351928, ...35132862, 31492838, 35254053
S283 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
Y307 Phosphorylation PhosphoSitePlus
S311 O-Glycosylation GlyGen 33214551, 32938750, 34019948, ...29351928, 35132862, 31492838, 35254053
S311 Phosphorylation PhosphoSitePlus
T313 O-Glycosylation GlyGen 33214551, 34019948, 29351928, ...35132862, 31492838, 35254053
T313 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S321 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
S333 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 19690332
T335 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S388 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S392 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S395 Phosphorylation PhosphoSitePlus
S460 O-Glycosylation GlyGen 33214551, 34019948, 29351928, ...35132862, 31492838, 35254053
S462 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
R503 Methylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
K519 Sumoylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus   UniProt 23186163
S545 Phosphorylation PhosphoSitePlus
K550 Sumoylation PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus   UniProt 19690332
S558 Phosphorylation PhosphoSitePlus   UniProt 23186163
S559 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
T560 Phosphorylation PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
K612 Ubiquitination PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
K653 Ubiquitination PhosphoSitePlus
T664 O-Glycosylation GlyGen 33214551, 34019948, 29351928, ...35132862, 31492838, 35254053
Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation HPRD 19664994
S79 Phosphorylation HPRD 19651622
S83 Phosphorylation HPRD 18669648
S89 Phosphorylation HPRD 18669648
S305 Phosphorylation HPRD 18669648
T313 Phosphorylation HPRD 19651622, 18669648
S333 Phosphorylation HPRD 17525332
S386 Phosphorylation HPRD 19651622
S534 Phosphorylation HPRD 20068231
S540 Phosphorylation HPRD 19651622
S552 Phosphorylation HPRD 20068231
T557 Phosphorylation HPRD 19651622
S558 Phosphorylation HPRD 19651622
S559 Phosphorylation HPRD 19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S135 Phosphorylation HPRD 18669648
T143 Phosphorylation HPRD 19651622, 18669648
S163 Phosphorylation HPRD 17525332
S216 Phosphorylation HPRD 19651622
S364 Phosphorylation HPRD 20068231
S370 Phosphorylation HPRD 19651622
S382 Phosphorylation HPRD 20068231
T387 Phosphorylation HPRD 19651622
S388 Phosphorylation HPRD 19651622
S389 Phosphorylation HPRD 19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation HPRD 19664994
S79 Phosphorylation HPRD 19651622
S83 Phosphorylation HPRD 18669648
S89 Phosphorylation HPRD 18669648
S305 Phosphorylation HPRD 18669648
T313 Phosphorylation HPRD 19651622, 18669648
S333 Phosphorylation HPRD 17525332
S385 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
Y389 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
S558 Phosphorylation HPRD 20068231
S564 Phosphorylation HPRD 19651622
S576 Phosphorylation HPRD 20068231
T581 Phosphorylation HPRD 19651622
S582 Phosphorylation HPRD 19651622
S583 Phosphorylation HPRD 19651622, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T62 I62 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S89 N89 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S98 Y98 Biomuta DOID:4159 / skin cancer [ cosmic ]
S98 F98 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y120 H120 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y120 C120 Biomuta DOID:1324 / lung cancer [ cosmic ]
K181 N181 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K185 R185 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K185 E185 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S216 F216 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ]
S263 A263 Biomuta DOID:2998 / testicular cancer [ cosmic ]
S281 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S301 R301 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S311 P311 Biomuta DOID:4159 / skin cancer [ cosmic ]
S386 F386 Biomuta DOID:4159 / skin cancer [ cosmic ]
S395 Y395 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K397 E397 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S460 N460 Biomuta DOID:4159 / skin cancer [ cosmic ]
S462 * Biomuta DOID:3565 / meningioma [ cosmic ]
S464 L464 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S490 L490 Biomuta DOID:1612 / breast cancer [ cosmic ]
K550 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K612 N612 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K653 N653 Biomuta DOID:363 / uterine cancer [ icgc ]