iPTMnet Report for Q96T88 (UHRF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96T88 / UHRF1_HUMAN
Protein Name E3 ubiquitin-protein ligase UHRF1
Gene Name Name: UHRF1
Synonyms:ICBP90,NP95,RNF106;
Organism Homo sapiens (Human)

PRO ID PR:Q96T88
DAG View
PRO Name E3 ubiquitin-protein ligase UHRF1 (human)
Definition An E3 ubiquitin-protein ligase UHRF1 that is encoded in the genome of human.
Short Label hUHRF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96T88 (UHRF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation PhosphoSitePlus
K24 Sumoylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
S76 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K84 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S91 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T93 Phosphorylation PhosphoSitePlus
S95 Phosphorylation P48730 (CSNK1D) phospho.ELM   PhosphoSitePlus   Signor 18669648, 23297342
S104 Phosphorylation HPRD 18669648, 20068231, 18452278
S108 Phosphorylation HPRD 18669648, 17081983, 18452278
T117 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
K279 Sumoylation PhosphoSitePlus
S287 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 19690332, 20068231
S298 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P   UniProt 32428527, 22837395, 15178447
K303 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus   UniProt 23186163
K385 Sumoylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K399 Acetylation PhosphoSitePlus   UniProt 19608861
K399 Sumoylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
K490 Acetylation PhosphoSitePlus
T492 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
C497 S-Nitrosylation dbSNO 26338901
K500 Sumoylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K525 Sumoylation PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K531 Sumoylation PhosphoSitePlus
K546 Acetylation PhosphoSitePlus   UniProt 19608861
K546 Sumoylation PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
K563 Sumoylation PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K570 Sumoylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K600 Sumoylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K626 Sumoylation PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
S639 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   UniProt 22411829, 23186163, 17081983, ...18669648, 20068231, 16964243
K644 Acetylation PhosphoSitePlus
K646 Acetylation PhosphoSitePlus
K648 Acetylation PhosphoSitePlus
K650 Acetylation PhosphoSitePlus
K650 Methylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21406692, 27045799
R658 Methylation PhosphoSitePlus
S661 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus   RLIMS-P 30357346, 22072796
K670 Sumoylation PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
K692 Sumoylation PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
S707 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S709 Phosphorylation PhosphoSitePlus   UniProt 23186163
C724 Methylation IEDB 31844290
S751 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 20068231
S76 Phosphorylation HPRD 18669648, 20068231
S88 Phosphorylation HPRD 17081983
S91 Phosphorylation HPRD 18669648, 20068231, 18452278
T93 Phosphorylation HPRD 17081983
S95 Phosphorylation HPRD 18669648, 17081983, 18452278
T109 Phosphorylation HPRD 17081983
S171 Phosphorylation HPRD 17081983
S287 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
T428 Phosphorylation HPRD 20068231
S639 Phosphorylation HPRD 18669648, 17081983, 20068231
S661 Phosphorylation HPRD 18767875
S707 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S311 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
S674 Phosphorylation P24941 (CDK2) PhosphoSitePlus 26727879


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P26358 (DNMT1) S127 Q96T88 (UHRF1) decreased_association eFIP 20613874
Phosphorylation Q96T88 (UHRF1) S298 P18858 (LIG1) unknown eFIP 32428527


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000037504 (hDNMT1/UnPhos:1) Interaction PR:Q96T88 (hUHRF1) PRO 20613874
PR:000037505 (hDNMT1/Phos:1) decreased Interaction PR:Q96T88 (hUHRF1) PRO 20613874
PR:000037506 (hDNMT1/Phos:2) decreased Interaction PR:Q96T88 (hUHRF1) PRO 20613874


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S88 P88 Biomuta DOID:363 / uterine cancer [ cosmic ]
S95 F95 Biomuta DOID:4159 / skin cancer [ cosmic ]
S119 N119 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K136 N136 Biomuta DOID:4159 / skin cancer [ cosmic ]
S393 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S393 A393 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y418 C418 Biomuta DOID:1324 / lung cancer [ cosmic ]
S496 C496 Biomuta DOID:1612 / breast cancer [ cosmic ]
K568 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K570 R570 Biomuta DOID:263 / kidney cancer [ cosmic ]
K600 N600 Biomuta DOID:3571 / liver cancer [ cosmic ]
S651 L651 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S661 F661 Biomuta [ cosmic ]
S751 Y751 Biomuta DOID:1324 / lung cancer [ cosmic ]