iPTMnet Report for Q96T60 (PNKP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96T60 / PNKP_HUMAN
Protein Name Bifunctional polynucleotide phosphatase/kinase
Gene Name Name: PNKP
Organism Homo sapiens (Human)

PRO ID PR:Q96T60
DAG View
PRO Name bifunctional polynucleotide phosphatase/kinase (human)
Definition A bifunctional polynucleotide phosphatase/kinase that is encoded in the genome of human.
Short Label hPNKP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96T60 (PNKP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S14 Phosphorylation PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
S114 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 17525332, ...21824916, 33332469
S114 Phosphorylation P78527 (PRKDC) Signor 21824916
S114 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor 21824916
T118 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...17525332, 18669648, 33332469, 24275569, 19690332, 20068231
T122 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 18669648, ...33332469, 19690332
S126 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17525332, 21824916, 33332469
S126 Phosphorylation P78527 (PRKDC) Signor 21824916
S126 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor 21824916
K142 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
K183 Acetylation PhosphoSitePlus
K183 Sumoylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
R224 Methylation PhosphoSitePlus
K226 Acetylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T111 Phosphorylation HPRD 19664995
S114 Phosphorylation HPRD 17525332, 20058876, 18077418
T118 Phosphorylation HPRD 19413330, 17525332, 18077418, ...19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 20068231
T122 Phosphorylation HPRD 19413330, 18077418, 18452278, ...18669648, 17081983
S126 Phosphorylation HPRD 17525332, 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S114 P114 Biomuta [ cosmic ]
T118 N118 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T122 A122 Biomuta DOID:1324 / lung cancer [ cosmic ]
S126 F126 Biomuta DOID:363 / uterine cancer [ icgc ]
R224 H224 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R224 C224 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]