iPTMnet Report for Q96T60 (PNKP)
Protein Information
UniProt AC / UniProt ID | Q96T60 / PNKP_HUMAN |
Protein Name | Bifunctional polynucleotide phosphatase/kinase |
Gene Name | Name: PNKP |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q96T60 |
PRO Name | bifunctional polynucleotide phosphatase/kinase (human) |
Definition | A bifunctional polynucleotide phosphatase/kinase that is encoded in the genome of human. |
Short Label | hPNKP |
Category | organism-gene |
Q96T60 (PNKP) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 22814378 | ||
S14 | Phosphorylation | score1 | PhosphoSitePlus | |||
T109 | Phosphorylation | score1 | PhosphoSitePlus | |||
T111 | Phosphorylation | score1 | PhosphoSitePlus | |||
S114 | Phosphorylation | Q13315 (ATM) , P78527 (PRKDC) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 23186163, 17525332, ... | |
T118 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 21406692, 23186163, 17081983, ... | ||
T122 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 23186163, 17081983, 18669648, ... | ||
S126 | Phosphorylation | P78527 (PRKDC) , Q13315 (ATM) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 17525332, 21824916, 33332469 | |
K142 | Ubiquitination | score1 | PhosphoSitePlus | |||
S143 | Phosphorylation | score1 | PhosphoSitePlus | |||
K183 | Acetylation | score1 | PhosphoSitePlus | |||
K183 | Sumoylation | score1 | PhosphoSitePlus | |||
K183 | Ubiquitination | score1 | PhosphoSitePlus | |||
R224 | Methylation | score1 | PhosphoSitePlus | |||
K226 | Acetylation | score1 | PhosphoSitePlus | |||
K226 | Ubiquitination | score1 | PhosphoSitePlus | |||
S364 | Phosphorylation | score1 | PhosphoSitePlus | |||
S379 | Phosphorylation | score1 | PhosphoSitePlus | |||
K484 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T111 | Phosphorylation | score0 | HPRD | 19664995 | ||
S114 | Phosphorylation | score0 | HPRD | 17525332, 20058876, 18077418 | ||
T118 | Phosphorylation | score0 | HPRD | 19413330, 17525332, 18077418, ... | ||
T122 | Phosphorylation | score0 | HPRD | 19413330, 18077418, 18452278, ... | ||
S126 | Phosphorylation | score0 | HPRD | 17525332, 18077418 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S114 | P114 | Biomuta | [ cosmic ] | |
T118 | N118 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
T122 | A122 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S126 | F126 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
R224 | H224 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
R224 | C224 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |