iPTMnet Report for Q96SW2 (CRBN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96SW2 / CRBN_HUMAN
Protein Name Protein cereblon
Gene Name Name: CRBN
ORFNames:AD-006;
Organism Homo sapiens (Human)

PRO ID PR:Q96SW2
DAG View
PRO Name protein cereblon (human)
Definition A protein cereblon that is encoded in the genome of human.
Short Label hCRBN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96SW2 (CRBN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation PhosphoSitePlus   UniProt 23186163
K43 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
C394 Methylation IEDB 31844290
S410 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
C441 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S174 P174 Biomuta DOID:1319 / brain cancer [ cosmic ]
S410 P410 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S410 L410 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]