Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96M69 / LRGUK_HUMAN
Protein Name Leucine-rich repeat and guanylate kinase domain-containing protein
Gene Name Name: LRGUK
Organism Homo sapiens (Human)

PRO ID PR:Q96M69
DAG View
PRO Name leucine-rich repeat and guanylate kinase domain-containing protein (human)
Definition A leucine-rich repeat and guanylate kinase domain-containing protein that is encoded in the genome of human.
Short Label hLRGUK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96M69 (LRGUK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation HPRD   PhosphoSitePlus 17924679
Y529 Phosphorylation PhosphoSitePlus
Y540 Phosphorylation PhosphoSitePlus
Y543 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 T15 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y322 C322 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S560 Y560 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]