iPTMnet Report for Q96LW4 (PRIMPOL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96LW4 / PRIPO_HUMAN
Protein Name DNA-directed primase/polymerase protein
Gene Name Name: PRIMPOL
Synonyms:CCDC111;
Organism Homo sapiens (Human)

PRO ID PR:Q96LW4
DAG View
PRO Name DNA-directed primase/polymerase protein (human)
Definition A DNA-directed primase/polymerase protein that is encoded in the genome of human.
Short Label hPRIMPOL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96LW4 (PRIMPOL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Ubiquitination PhosphoSitePlus
S25 O-Glycosylation GlyGen 30379171
S33 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S259 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K232 T232 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S259 R259 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K269 N269 Biomuta DOID:363 / uterine cancer [ icgc ]
S544 N544 Biomuta DOID:1319 / brain cancer [ icgc ]