iPTMnet Report for Q96LW4 (PRIMPOL)
Protein Information
UniProt AC / UniProt ID | Q96LW4 / PRIPO_HUMAN |
Protein Name | DNA-directed primase/polymerase protein |
Gene Name | Name: PRIMPOL Synonyms:CCDC111; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q96LW4 |
PRO Name | DNA-directed primase/polymerase protein (human) |
Definition | A DNA-directed primase/polymerase protein that is encoded in the genome of human. |
Short Label | hPRIMPOL |
Category | organism-gene |
Q96LW4 (PRIMPOL) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K10 | Ubiquitination | score1 | PhosphoSitePlus | |||
S25 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
S33 | Phosphorylation | score1 | PhosphoSitePlus | |||
S207 | Phosphorylation | score1 | PhosphoSitePlus | |||
K232 | Ubiquitination | score1 | PhosphoSitePlus | |||
K237 | Ubiquitination | score1 | PhosphoSitePlus | |||
K248 | Ubiquitination | score1 | PhosphoSitePlus | |||
S255 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 19690332 | ||
S259 | Phosphorylation | score1 | PhosphoSitePlus | |||
S260 | Phosphorylation | score1 | PhosphoSitePlus | |||
K269 | Ubiquitination | score1 | PhosphoSitePlus | |||
K275 | Ubiquitination | score1 | PhosphoSitePlus | |||
S365 | Phosphorylation | score1 | PhosphoSitePlus | |||
S386 | Phosphorylation | score1 | PhosphoSitePlus | |||
K445 | Ubiquitination | score1 | PhosphoSitePlus | |||
S499 | Phosphorylation | score1 | PhosphoSitePlus | |||
S544 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K232 | T232 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
S259 | R259 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
K269 | N269 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S544 | N544 | Biomuta | DOID:1319 / brain cancer [ icgc ] |