iPTMnet Report for Q96JZ2 (HSH2D)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96JZ2 / HSH2D_HUMAN
Protein Name Hematopoietic SH2 domain-containing protein
Gene Name Name: HSH2D
Synonyms:ALX;
Organism Homo sapiens (Human)

PRO ID PR:Q96JZ2
DAG View
PRO Name hematopoietic SH2 domain-containing protein (human)
Definition A hematopoietic SH2 domain-containing protein that is encoded in the genome of human.
Short Label hHSH2D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96JZ2 (HSH2D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y135 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
T259 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S296 Phosphorylation HPRD 20058876
S298 Phosphorylation HPRD 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y135 N135 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S194 Y194 Biomuta DOID:4159 / skin cancer [ cosmic ]
S194 P194 Biomuta DOID:4159 / skin cancer [ cosmic ]
S194 C194 Biomuta DOID:363 / uterine cancer [ cosmic ]
S194 F194 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S206 C206 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T259 I259 Biomuta DOID:3571 / liver cancer [ cosmic ]
S260 L260 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S260 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S298 I298 Biomuta DOID:1324 / lung cancer [ cosmic ]
S319 F319 Biomuta DOID:4159 / skin cancer [ cosmic ]
S319 P319 Biomuta DOID:4159 / skin cancer [ cosmic ]