iPTMnet Report for Q96IZ0 (PAWR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96IZ0 / PAWR_HUMAN
Protein Name PRKC apoptosis WT1 regulator protein
Gene Name Name: PAWR
Synonyms:PAR4;
Organism Homo sapiens (Human)

PRO ID PR:Q96IZ0
DAG View
PRO Name PRKC apoptosis WT1 regulator protein (human)
Definition A PRKC apoptosis WT1 regulator protein that is encoded in the genome of human.
Short Label hPAWR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96IZ0 (PAWR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S9 O-Glycosylation GlyGen 31373491
S10 O-Glycosylation GlyGen 31373491
S15 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
S108 O-Glycosylation GlyGen 23301498, 28411811, 31373491, ...31492838, 34019948
S108 Phosphorylation PhosphoSitePlus   UniProt 24275569
S116 O-Glycosylation GlyGen 31373491
S118 O-Glycosylation GlyGen 31373491
K146 Methylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus   RLIMS-P 31834925
C173 S-Nitrosylation dbSNO 26338901
Y177 Phosphorylation PhosphoSitePlus
T221 O-Glycosylation GlyGen 31373491
S223 Phosphorylation HPRD   PhosphoSitePlus 19651622
Y226 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
K227 Methylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S228 O-Glycosylation GlyGen 31373491
S228 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
T229 O-Glycosylation GlyGen 31373491
T229 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
T230 O-Glycosylation GlyGen 31373491
T230 Phosphorylation HPRD   PhosphoSitePlus 18212344
S231 O-Glycosylation GlyGen 31373491
S231 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 17287340, 24457960, ...19664995, 18669648, 23186163, 18212344
S233 O-Glycosylation GlyGen 23301498, 28411811, 31373491, ...31492838, 34019948
S233 Phosphorylation HPRD   PhosphoSitePlus 19413330
S238 O-Glycosylation GlyGen 23301498, 28411811, 31373491, ...31492838, 34019948
Y241 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S259 Phosphorylation HPRD   PhosphoSitePlus 19664994, 18212344
T261 Phosphorylation HPRD   PhosphoSitePlus 18212344
T267 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K296 Acetylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96IZ0 (PAWR) T163 O14974 (PPP1R12A) inhibited_association eFIP 31834925


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S95 F95 Biomuta DOID:4159 / skin cancer [ cosmic ]
S118 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K146 N146 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S228 I228 Biomuta DOID:363 / uterine cancer [ icgc ]
S231 R231 Biomuta DOID:4362 / cervical cancer [ icgc ]
Y241 C241 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]