iPTMnet Report for Q96G74 (OTUD5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96G74 / OTUD5_HUMAN
Protein Name OTU domain-containing protein 5
Gene Name Name: OTUD5
Organism Homo sapiens (Human)

PRO ID PR:Q96G74
DAG View
PRO Name OTU domain-containing protein 5 (human)
Definition An OTU domain-containing protein 5 that is encoded in the genome of human.
Short Label hOTUD5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96G74 (OTUD5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R32 Methylation PhosphoSitePlus
S64 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18669648, ...20068231, 22245969
S165 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 24275569, ...19690332, 22245969
Y175 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 22245969
S177 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 15302935, 33417762, ...33748114, 32655987, 18669648, 19690332, 22245969
Y181 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T195 Phosphorylation UniProt 33110214
K205 Ubiquitination PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
S328 Phosphorylation UniProt 33110214
S337 Phosphorylation UniProt 33110214
K343 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus   UniProt 33110214
K385 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
T449 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S450 Phosphorylation PhosphoSitePlus
S452 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 33110214
S457 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
T507 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336, 33110214, ...22245969
S508 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 33110214
S512 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y514 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S64 Phosphorylation HPRD 18691976, 20230923, 19651622, ...18669648, 20068231, 17924679
S165 Phosphorylation HPRD 19413330, 19664994, 19651622, ...18669648, 19415658, 20068231
Y175 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19415658, 20068231
S177 Phosphorylation HPRD 18669648, 15302935, 20068231, ...18452278
Y181 Phosphorylation HPRD 18669648
T449 Phosphorylation HPRD 18669648
S452 Phosphorylation HPRD 18669648, 20068231
T507 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19664995, 20068231
S508 Phosphorylation HPRD 18669648, 19664995, 20068231
S512 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R32 C32 Biomuta DOID:4159 / skin cancer [ cosmic ]
S64 L64 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K205 M205 Biomuta DOID:4159 / skin cancer [ cosmic ]
S460 L460 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S489 L489 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S527 P527 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]