iPTMnet Report for Q96G46 (DUS3L)
Protein Information
UniProt AC / UniProt ID | Q96G46 / DUS3L_HUMAN |
Protein Name | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like |
Gene Name | Name: DUS3L |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q96G46 |
PRO Name | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (human) |
Definition | A tRNA-dihydrouridine synthase 3-like that is encoded in the genome of human. |
Short Label | hDUS3L |
Category | organism-gene |
Q96G46 (DUS3L) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330, 22814378 | ||
K38 | Ubiquitination | score1 | PhosphoSitePlus | |||
K48 | Acetylation | score1 | PhosphoSitePlus | |||
K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
K73 | Acetylation | score1 | PhosphoSitePlus | |||
K73 | Ubiquitination | score1 | PhosphoSitePlus | |||
K101 | Ubiquitination | score1 | PhosphoSitePlus | |||
K114 | Ubiquitination | score1 | PhosphoSitePlus | |||
K120 | Ubiquitination | score1 | PhosphoSitePlus | |||
K134 | Ubiquitination | score1 | PhosphoSitePlus | |||
K154 | Ubiquitination | score1 | PhosphoSitePlus | |||
K212 | Ubiquitination | score1 | PhosphoSitePlus | |||
S236 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231, ... | ||
T240 | Phosphorylation | score1 | PhosphoSitePlus | |||
T271 | Phosphorylation | score1 | PhosphoSitePlus | |||
S272 | Phosphorylation | score1 | PhosphoSitePlus | |||
T273 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 19690332, 24275569 | ||
S276 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 24275569 | ||
S277 | Phosphorylation | score1 | PhosphoSitePlus | |||
T281 | Phosphorylation | score1 | PhosphoSitePlus | |||
K306 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y308 | Phosphorylation | score1 | PhosphoSitePlus | |||
K354 | Methylation | score1 | PhosphoSitePlus | |||
K403 | Ubiquitination | score1 | PhosphoSitePlus | |||
K404 | Ubiquitination | score1 | PhosphoSitePlus | |||
K416 | Ubiquitination | score1 | PhosphoSitePlus | |||
K435 | Ubiquitination | score1 | PhosphoSitePlus | |||
K526 | Ubiquitination | score1 | PhosphoSitePlus | |||
K534 | Ubiquitination | score1 | PhosphoSitePlus | |||
S542 | Phosphorylation | score1 | PhosphoSitePlus | |||
S543 | Phosphorylation | score1 | PhosphoSitePlus | |||
S544 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y610 | Phosphorylation | score1 | PhosphoSitePlus | |||
K619 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S236 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
T240 | Phosphorylation | score0 | HPRD | 20068231 | ||
T271 | Phosphorylation | score0 | HPRD | 17081983 | ||
S272 | Phosphorylation | score0 | HPRD | 20068231 | ||
T273 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 18669648, ... | ||
S276 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 18669648, ... | ||
S277 | Phosphorylation | score0 | HPRD | 19413330, 19664995, 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K120 | N120 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
S236 | N236 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K403 | N403 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
S543 | L543 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] |