iPTMnet Report for Q96FA3 (PELI1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96FA3 / PELI1_HUMAN
Protein Name E3 ubiquitin-protein ligase pellino homolog 1
Gene Name Name: PELI1
Synonyms:PRISM;
Organism Homo sapiens (Human)

PRO ID PR:Q96FA3
DAG View
PRO Name E3 ubiquitin-protein ligase pellino homolog 1 (human)
Definition An E3 ubiquitin-protein ligase pellino homolog 1 that is encoded in the genome of human.
Short Label hPELI1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96FA3 (PELI1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
S39 Phosphorylation IEDB   PhosphoSitePlus 27920218
K48 Acetylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
C61 Methylation IEDB 31844290
S70 Phosphorylation P51617 (IRAK1) , Q9NWZ3 (IRAK4) PhosphoSitePlus 21204785, 19264966
S76 Phosphorylation Q9UHD2 (TBK1) , Q9NWZ3 (IRAK4) , Q14164 (IKBKE) , P51617 (IRAK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 12496252, 21204785, 19264966
S78 Phosphorylation Q9NWZ3 (IRAK4) , P51617 (IRAK1) PhosphoSitePlus   Signor 12496252, 21204785, 19264966
T80 Phosphorylation Q14164 (IKBKE) , P51617 (IRAK1) , Q9UHD2 (TBK1) , Q9NWZ3 (IRAK4) neXtProt   PhosphoSitePlus 21204785, 19264966
S82 Phosphorylation P51617 (IRAK1) , Q9NWZ3 (IRAK4) PhosphoSitePlus   Signor 12496252, 21204785, 19264966
T86 Phosphorylation Q9NWZ3 (IRAK4) , P51617 (IRAK1) PhosphoSitePlus   Signor 12496252, 21204785, 19264966
S121 Phosphorylation RLIMS-P 30952868
S125 Phosphorylation P51617 (IRAK1) PhosphoSitePlus 21204785
T127 Phosphorylation P51617 (IRAK1) , Q9NWZ3 (IRAK4) PhosphoSitePlus   RLIMS-P 21204785, 19264966, 30952868
Y154 Phosphorylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
K202 Sumoylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
T264 Phosphorylation PhosphoSitePlus
K266 Sumoylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
C282 Methylation IEDB 31844290
T288 Phosphorylation P51617 (IRAK1) , Q14164 (IKBKE) , Q9UHD2 (TBK1) , Q9NWZ3 (IRAK4) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 12496252, 21204785, 19264966
S293 Phosphorylation P51617 (IRAK1) , Q9UHD2 (TBK1) , Q9NWZ3 (IRAK4) , Q14164 (IKBKE) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 12496252, 21204785, 19264966
K295 Sumoylation PhosphoSitePlus
K297 Sumoylation PhosphoSitePlus
K303 Sumoylation PhosphoSitePlus
S380 Phosphorylation RLIMS-P 30952868


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S70 G70 Biomuta DOID:363 / uterine cancer [ icgc ]
S78 L78 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T127 A127 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S380 F380 Biomuta DOID:4159 / skin cancer [ cosmic ]