iPTMnet Report for Q96CB8 (INTS12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96CB8 / INT12_HUMAN
Protein Name Integrator complex subunit 12
Gene Name Name: INTS12
Synonyms:PHF22;ORFNames:SBBI22;
Organism Homo sapiens (Human)

PRO ID PR:Q96CB8
DAG View
PRO Name integrator complex subunit 12 (human)
Definition An integrator complex subunit 12 that is encoded in the genome of human.
Short Label hINTS12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96CB8 (INTS12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Sumoylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K105 Sumoylation PhosphoSitePlus
K122 Methylation PhosphoSitePlus
T125 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S127 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19651622, 20068231, ...18691976
S128 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 23186163, ...18452278, 18669648, 24275569, 20068231
K192 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
K229 Acetylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K254 Sumoylation PhosphoSitePlus
K263 Acetylation PhosphoSitePlus
T300 O-Glycosylation GlyGen 34846842
S301 O-Glycosylation GlyGen 34846842
S311 O-Glycosylation GlyGen 33214551, 32574038, 30059200, ...29351928, 34019948, 35254053
T314 O-Glycosylation GlyGen 33214551, 32574038, 30059200, ...29351928, 34019948, 35254053
T318 O-Glycosylation GlyGen 33214551, 32574038, 30059200, ...29351928, 34019948, 35254053
K320 Ubiquitination PhosphoSitePlus
T323 O-Glycosylation GlyGen 33214551, 32574038, 30059200, ...29351928, 34019948, 35254053
S324 O-Glycosylation GlyGen 33214551, 32574038, 30059200, ...29351928, 34019948, 35254053
S325 O-Glycosylation GlyGen 33214551, 32574038, 30059200, ...29351928, 34019948, 35254053
K329 Acetylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
T338 O-Glycosylation GlyGen 33214551, 32574038, 30059200, ...29351928, 34019948, 35254053
T355 Phosphorylation PhosphoSitePlus
K361 Acetylation PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
K419 Methylation PhosphoSitePlus
S427 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18691976, 18669648
K433 Methylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
K446 Acetylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K91 N91 Biomuta DOID:4159 / skin cancer [ cosmic ]
K91 R91 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T318 S318 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T323 A323 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S324 L324 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
T355 S355 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T355 M355 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K361 N361 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S427 F427 Biomuta DOID:4159 / skin cancer [ cosmic ]
S437 A437 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S437 L437 Biomuta DOID:4159 / skin cancer [ cosmic ]
K446 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K446 E446 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]