iPTMnet Report for Q92890 (UFD1)
Protein Information
| UniProt AC / UniProt ID | Q92890 / UFD1_HUMAN |
| Protein Name | Ubiquitin recognition factor in ER-associated degradation protein 1 |
| Gene Name | Name: UFD1 Synonyms:UFD1L; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q92890 |
| PRO Name | ubiquitin recognition factor in ER-associated degradation protein 1 (human) |
| Definition | A ubiquitin recognition factor in ER-associated degradation protein 1 that is encoded in the genome of human. |
| Short Label | hUFD1 |
| Category | organism-gene |
Q92890 (UFD1) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 19413330 | ||
| S3 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S27 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S29 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K45 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K68 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K72 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T78 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C80 | Methylation | score1 | IEDB | 31844290 | ||
| C92 | Methylation | score1 | IEDB | 31844290 | ||
| K124 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S129 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| T136 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K139 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K165 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R170 | Methylation | score1 | PhosphoSitePlus | |||
| K175 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K178 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K198 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S209 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T210 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S217 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y219 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S229 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S231 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231 | ||
| K238 | Acetylation | score1 | PhosphoSitePlus | |||
| K240 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S245 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231 | ||
| S247 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231 | ||
| K250 | Acetylation | score1 | PhosphoSitePlus | |||
| K250 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K255 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y261 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K264 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K267 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K279 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S299 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692, 23186163, 18669648, ... | ||
| K302 | Ubiquitination | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T210 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S231 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S245 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231 | ||
| S247 | Phosphorylation | score0 | HPRD | 17322306, 19651622, 18669648, ... | ||
| S299 | Phosphorylation | score0 | HPRD | 18491316, 17287340, 18767875, ... |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S3 | Y3 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S27 | F27 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S29 | F29 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| C80 | Y80 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] | |
| K124 | R124 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K124 | T124 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| T136 | A136 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K198 | N198 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S209 | L209 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
| S231 | F231 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K250 | N250 | Biomuta | DOID:3953 / adrenal gland cancer [ cosmic ] | |
| K255 | E255 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] | |
| Y261 | C261 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| K280 | E280 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
DAG View