iPTMnet Report for Q92824 (PCSK5)
Protein Information
UniProt AC / UniProt ID | Q92824 / PCSK5_HUMAN |
Protein Name | Proprotein convertase subtilisin/kexin type 5 precursor |
Gene Name | Name: PCSK5 Synonyms:PC5,PC6; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q92824 |
PRO Name | proprotein convertase subtilisin/kexin type 5 (human) |
Definition | A proprotein convertase subtilisin/kexin type 5 that is encoded in the genome of human. |
Short Label | hPCSK5 |
Category | organism-gene |
Q92824 (PCSK5) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K56 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y71 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y72 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y75 | Phosphorylation | score1 | PhosphoSitePlus | |||
S148 | Phosphorylation | score1 | PhosphoSitePlus | |||
T250 | Phosphorylation | score1 | PhosphoSitePlus | |||
S305 | Phosphorylation | score1 | PhosphoSitePlus | |||
S353 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y489 | Phosphorylation | score1 | PhosphoSitePlus | |||
T754 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1263 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1264 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1270 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1271 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1424 | Phosphorylation | score1 | PhosphoSitePlus | |||
T1436 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1572 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1596 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y72 | D72 | Biomuta | DOID:10283 / prostate cancer [ icgc ] | |
Y75 | S75 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S1424 | F1424 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S1424 | Y1424 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
S1596 | F1596 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |