iPTMnet Report for Q92622 (RUBCN)
Protein Information
UniProt AC / UniProt ID | Q92622 / RUBIC_HUMAN |
Protein Name | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein |
Gene Name | Name: RUBCN Synonyms:KIAA0226; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q92622 |
PRO Name | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (human) |
Definition | A Run domain Beclin-1-interacting and cysteine-rich domain-containing protein that is encoded in the genome of human. |
Short Label | hRUBCN |
Category | organism-gene |
Q92622 (RUBCN) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S44 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31752345 | ||
K50 | Ubiquitination | score1 | PhosphoSitePlus | |||
S92 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31752345 | ||
K194 | Ubiquitination | score1 | PhosphoSitePlus | |||
S197 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 23186163, 19369195 | ||
S246 | Phosphorylation | score1 | PhosphoSitePlus | |||
T247 | Phosphorylation | score1 | PhosphoSitePlus | |||
S248 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S266 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195, 23186163 | ||
T272 | Phosphorylation | score1 | PhosphoSitePlus | |||
S378 | Phosphorylation | score1 | PhosphoSitePlus | |||
S387 | Phosphorylation | score1 | PhosphoSitePlus | |||
S388 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S390 | Phosphorylation | score1 | PhosphoSitePlus | |||
K403 | Ubiquitination | score1 | PhosphoSitePlus | |||
S408 | Phosphorylation | score1 | PhosphoSitePlus | |||
S410 | Phosphorylation | score1 | PhosphoSitePlus | |||
S416 | Phosphorylation | score1 | PhosphoSitePlus | |||
T444 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y449 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y457 | Phosphorylation | score1 | PhosphoSitePlus | |||
S469 | Phosphorylation | score1 | PhosphoSitePlus | |||
S473 | Phosphorylation | score1 | PhosphoSitePlus | |||
S479 | Phosphorylation | score1 | PhosphoSitePlus | |||
S528 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
S562 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S570 | Phosphorylation | score1 | PhosphoSitePlus | |||
S577 | Phosphorylation | score1 | PhosphoSitePlus | |||
S581 | Phosphorylation | score1 | PhosphoSitePlus | |||
S583 | Phosphorylation | score1 | PhosphoSitePlus | |||
S585 | Phosphorylation | score1 | PhosphoSitePlus | |||
S609 | Phosphorylation | score1 | PhosphoSitePlus | |||
S612 | Phosphorylation | score1 | PhosphoSitePlus | |||
S615 | Phosphorylation | score1 | PhosphoSitePlus | |||
K660 | Ubiquitination | score1 | PhosphoSitePlus | |||
S671 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 19690332 | ||
K682 | Ubiquitination | score1 | PhosphoSitePlus | |||
T709 | Phosphorylation | score1 | PhosphoSitePlus | |||
K716 | Ubiquitination | score1 | PhosphoSitePlus | |||
T728 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y732 | Phosphorylation | score1 | PhosphoSitePlus | |||
K734 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y772 | Phosphorylation | score1 | PhosphoSitePlus | |||
S774 | Phosphorylation | score1 | PhosphoSitePlus | |||
S777 | Phosphorylation | score1 | PhosphoSitePlus | |||
K778 | Ubiquitination | score1 | PhosphoSitePlus | |||
K830 | Ubiquitination | score1 | PhosphoSitePlus | |||
S851 | Phosphorylation | score1 | PhosphoSitePlus | |||
T856 | Phosphorylation | score1 | PhosphoSitePlus | |||
K860 | Ubiquitination | score1 | PhosphoSitePlus | |||
K921 | Ubiquitination | score1 | PhosphoSitePlus | |||
S952 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S197 | Phosphorylation | score0 | HPRD | 18691976 | ||
S266 | Phosphorylation | score0 | HPRD | 18691976 | ||
T272 | Phosphorylation | score0 | HPRD | 18691976 | ||
S410 | Phosphorylation | score0 | HPRD | 18691976 | ||
S577 | Phosphorylation | score0 | HPRD | 18691976 | ||
S581 | Phosphorylation | score0 | HPRD | 18691976 | ||
S583 | Phosphorylation | score0 | HPRD | 18691976 | ||
S585 | Phosphorylation | score0 | HPRD | 18691976 | ||
S667 | Phosphorylation | score0 | HPRD | 18691976 | ||
S671 | Phosphorylation | score0 | HPRD | 18691976 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S92 | N92 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
S197 | R197 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S266 | L266 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
S410 | L410 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, tcga ] | |
S562 | I562 | Biomuta | DOID:3953 / adrenal gland cancer [ cosmic ] | |
S609 | F609 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S609 | P609 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T709 | M709 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
K778 | N778 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K778 | E778 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S851 | L851 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
K860 | * | Biomuta | DOID:263 / kidney cancer [ cosmic ] |