iPTMnet Report for Q92542 (NCSTN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92542 / NICA_HUMAN
Protein Name Nicastrin precursor
Gene Name Name: NCSTN
Synonyms:KIAA0253;ORFNames:UNQ1874/PRO4317;
Organism Homo sapiens (Human)

PRO ID PR:Q92542
DAG View
PRO Name nicastrin (human)
Definition A nicastrin that is encoded in the genome of human.
Short Label hNCSTN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92542 (NCSTN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N45 N-Glycosylation GlyGen   UniProt 34089345, 19159218, 24190977, ...26280335, 30630874, 29741879, 30598546
N55 N-Glycosylation GlyGen   UniProt 26280335, 30598546, 30630874, ...24190977
C62 Methylation IEDB 31844290
K101 Ubiquitination PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
S124 Phosphorylation IEDB 32387766
K127 Ubiquitination PhosphoSitePlus
N142 N-Glycosylation GlyGen 24190977
N187 N-Glycosylation GlyGen   UniProt 26280335, 30598546, 30630874, ...19159218
S234 Phosphorylation IEDB 30784271, 32387766
N264 N-Glycosylation GlyGen   UniProt 24190977, 23090970, 26280335, ...30630874, 29741879, 30598546
K349 Acetylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
N387 N-Glycosylation GlyGen   UniProt 19159218, 24190977, 26280335, ...30630874, 12754519, 30598546
N392 N-Glycosylation GlyGen 24190977
K403 Ubiquitination PhosphoSitePlus
N417 N-Glycosylation GlyGen 29741879, 24190977
S419 O-Glycosylation GlyGen 33214551, 34725712, 22503002, ...35254053, 34019948, 32119511, 35289036
S425 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
R434 Methylation PhosphoSitePlus
N435 N-Glycosylation GlyGen   UniProt 34089345, 24190977, 26280335, ...30630874, 29741879, 30598546
S437 O-Glycosylation GlyGen 33214551, 34725712, 22503002, ...35254053, 34019948, 32119511, 35289036
S437 Phosphorylation O00141 (SGK1) PhosphoSitePlus   RLIMS-P 22590650, 25996556
S445 O-Glycosylation GlyGen 33214551, 34725712, 22503002, ...35254053, 34019948, 32119511, 35289036
N464 N-Glycosylation GlyGen   UniProt 26280335, 30598546, 30630874
T505 O-Glycosylation GlyGen 33214551, 34725712, 22503002, ...35254053, 34019948, 32119511, 35289036
N506 N-Glycosylation GlyGen   UniProt 26280335, 30598546, 30630874, ...29741879
N530 N-Glycosylation GlyGen   UniProt 24190977, 23090970, 26280335, ...30630874, 29741879, 30598546
N531 N-Glycosylation GlyGen 24190977
N562 N-Glycosylation GlyGen   UniProt 26280335, 30598546, 30630874
N573 N-Glycosylation GlyGen   UniProt 26280335, 30598546, 30630874
N580 N-Glycosylation GlyGen   UniProt 30630874
N612 N-Glycosylation GlyGen   UniProt 29741879, 24190977, 19349973
S632 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus
T649 Phosphorylation PhosphoSitePlus
T672 Phosphorylation PhosphoSitePlus
T674 Phosphorylation PhosphoSitePlus
S708 O-Glycosylation GlyGen 33214551, 34725712, 22503002, ...35254053, 34019948, 32119511, 35289036
S708 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K127 N127 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
N417 D417 Biomuta DOID:1612 / breast cancer [ cosmic ]
S419 F419 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S425 T425 Biomuta DOID:4159 / skin cancer [ cosmic ]
R434 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R434 G434 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R434 Q434 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S445 F445 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N464 H464 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N573 S573 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]