iPTMnet Report for Q92481 (TFAP2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92481 / AP2B_HUMAN
Protein Name Transcription factor AP-2-beta
Gene Name Name: TFAP2B
Organism Homo sapiens (Human)

PRO ID PR:Q92481
DAG View
PRO Name transcription factor AP-2-beta (human)
Definition A transcription factor AP-2-beta that is encoded in the genome of human.
Short Label hTFAP2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92481 (TFAP2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K21 Sumoylation PRO
S120 Phosphorylation PhosphoSitePlus
R126 Methylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
S258 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 31492751
S277 Phosphorylation RLIMS-P 31492751
K301 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S223 Phosphorylation HPRD 20068231
Y246 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049423 (hTFAP2B/Sumo:1) suK21 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R126 Q126 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R126 W126 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S242 A242 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S244 L244 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K245 E245 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S258 L258 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S277 L277 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
K354 T354 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K354 N354 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]