iPTMnet Report for Q8WVS4 (DYNC2I1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WVS4 / DC2I1_HUMAN
Protein Name Cytoplasmic dynein 2 intermediate chain 1
Gene Name Name: DYNC2I1
Synonyms:WDR60;
Organism Homo sapiens (Human)

PRO ID PR:Q8WVS4
DAG View
PRO Name cytoplasmic dynein 2 intermediate chain 1 (human)
Definition A cytoplasmic dynein 2 intermediate chain 1 that is encoded in the genome of human.
Short Label hDYNC2I1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WVS4 (DYNC2I1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus   UniProt 23186163
T75 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
S247 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S249 Phosphorylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K487 Methylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K691 Acetylation IEDB 34357683
K901 Ubiquitination PhosphoSitePlus
K1036 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S27 P27 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S79 R79 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S231 N231 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S249 F249 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ icgc ]
K414 N414 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K487 N487 Biomuta DOID:1324 / lung cancer [ cosmic ]
K529 R529 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K691 T691 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]