iPTMnet Report for Q8WV28 (BLNK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WV28 / BLNK_HUMAN
Protein Name B-cell linker protein
Gene Name Name: BLNK
Synonyms:BASH,SLP65;
Organism Homo sapiens (Human)

PRO ID PR:Q8WV28
DAG View
PRO Name B-cell linker protein (human)
Definition A B-cell linker protein that is encoded in the genome of human.
Short Label hBLNK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WV28 (BLNK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y72 Phosphorylation P43405 (SYK) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 12456653, 9697839, 16969585
Y84 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27381982, 12456653, 9697839
Y96 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12456653, 9697839, 19620627
S129 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus   RLIMS-P 22334673
Y178 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 12456653, 9697839
Y189 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 12456653, 9697839
T193 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
K405 Acetylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046486 (hBLNK/Phos:1) pY72,pY84,pY96,pY178,pY189 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y72 C72 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
Y84 C84 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S129 F129 Biomuta DOID:4159 / skin cancer [ cosmic ]
S243 C243 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S243 F243 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T253 M253 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ]
T253 A253 Biomuta DOID:263 / kidney cancer [ cosmic ]