iPTMnet Report for Q8TEW0 (PARD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TEW0 / PARD3_HUMAN
Protein Name Partitioning defective 3 homolog
Gene Name Name: PARD3
Synonyms:PAR3,PAR3A;
Organism Homo sapiens (Human)

PRO ID PR:Q8TEW0
DAG View
PRO Name partitioning defective 3 homolog (human)
Definition A partitioning defective 3 that is encoded in the genome of human.
Short Label hPARD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TEW0 (PARD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Acetylation PhosphoSitePlus
K22 Acetylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus   UniProt 24275569
T32 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus   UniProt 24275569
S94 Phosphorylation PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
S143 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S144 Phosphorylation Q7KZI7 (MARK2) phospho.ELM   PhosphoSitePlus 18220336, 22883624, 17081983, ...14653998
S154 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
T171 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus   UniProt 23186163
T175 Phosphorylation PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
K181 Methylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
R294 Methylation PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
C323 Methylation IEDB 31844290
S370 Phosphorylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S383 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 18220336, ...15302935, 18669648, 24275569, 24928906, 19690332, 20068231
S386 Phosphorylation PhosphoSitePlus
Y388 Phosphorylation PhosphoSitePlus
S437 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...34725712, 35254053
S474 Phosphorylation PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
S485 Phosphorylation PhosphoSitePlus
Y489 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 24275569
S523 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
T534 Phosphorylation PhosphoSitePlus
T579 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
T654 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
T668 Phosphorylation PhosphoSitePlus
K672 Acetylation PhosphoSitePlus
R673 Methylation PhosphoSitePlus
R682 Methylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus
S692 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S695 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S715 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S717 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
Y719 Phosphorylation PhosphoSitePlus
S720 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S728 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...19690332, 20068231
S730 Phosphorylation PhosphoSitePlus
A792 Phosphorylation UniProt 24275569
S803 Phosphorylation phospho.ELM 18669648
C806 Methylation IEDB 31844290
S807 Phosphorylation PhosphoSitePlus
S809 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S827 Phosphorylation P41743 (PRKCI) , Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22371556, 23186163, 12390250, ...22579248
T833 Phosphorylation PhosphoSitePlus   RLIMS-P 18267089
S837 Phosphorylation PhosphoSitePlus   UniProt 23186163
S840 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
S852 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...18088087, 19690332, 20068231
S873 Phosphorylation Q7KZI7 (MARK2) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 22883624, ...18669648, 20068231
S875 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
K885 Ubiquitination PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
S889 Phosphorylation phospho.ELM   PhosphoSitePlus 15721295
S892 Phosphorylation PhosphoSitePlus
T895 Phosphorylation PhosphoSitePlus
S924 Phosphorylation PhosphoSitePlus
Y933 Phosphorylation PhosphoSitePlus
T947 Phosphorylation PhosphoSitePlus
S958 Phosphorylation PhosphoSitePlus
S962 Phosphorylation O14965 (AURKA) , Q96GD4 (AURKB) neXtProt   PhosphoSitePlus   Signor   UniProt 19812038, 23186163
S967 Phosphorylation PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus   UniProt 23186163
S973 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1005 Acetylation PhosphoSitePlus
K1007 Acetylation PhosphoSitePlus
K1013 Acetylation PhosphoSitePlus
K1014 Acetylation PhosphoSitePlus
S1046 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1080 Phosphorylation PhosphoSitePlus
C1092 Methylation IEDB 31844290
Y1098 Phosphorylation PhosphoSitePlus
Y1104 Phosphorylation PhosphoSitePlus
S1116 Phosphorylation PhosphoSitePlus
Y1127 Phosphorylation P07947 (YES1) neXtProt   phospho.ELM   PhosphoSitePlus 15951569, 17053785
S1139 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus
S1146 Phosphorylation PhosphoSitePlus
T1147 Phosphorylation PhosphoSitePlus
T1176 Phosphorylation PhosphoSitePlus
Y1177 Phosphorylation PhosphoSitePlus
S1178 Phosphorylation PhosphoSitePlus
S1196 Phosphorylation PhosphoSitePlus
S1198 Phosphorylation PhosphoSitePlus
Y1221 Phosphorylation PhosphoSitePlus
S1222 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
S1239 Phosphorylation PhosphoSitePlus
Y1244 Phosphorylation PhosphoSitePlus
S1245 Phosphorylation PhosphoSitePlus
Y1259 Phosphorylation PhosphoSitePlus
S1260 Phosphorylation PhosphoSitePlus
S1261 Phosphorylation PhosphoSitePlus
Y1269 Phosphorylation PhosphoSitePlus
Y1310 Phosphorylation PhosphoSitePlus
S1312 Phosphorylation PhosphoSitePlus
Y1313 Phosphorylation PhosphoSitePlus
Y1321 Phosphorylation PhosphoSitePlus
S1335 Phosphorylation PhosphoSitePlus
S1337 Phosphorylation PhosphoSitePlus
T1347 Phosphorylation PhosphoSitePlus
S1356 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S143 Phosphorylation HPRD 20068231, 18452278
S144 Phosphorylation HPRD 17081983, 18452278
S174 Phosphorylation HPRD 19413330
T175 Phosphorylation HPRD 20068231
S383 Phosphorylation HPRD 15302935, 19664994, 19664995, ...19651622, 18669648, 20068231, 17924679
Y388 Phosphorylation HPRD 19901323, 15144186
Y489 Phosphorylation HPRD 17016520, 18083107
S533 Phosphorylation HPRD 19664995
T534 Phosphorylation HPRD 19664995
T579 Phosphorylation HPRD 19664994
S692 Phosphorylation HPRD 18669648, 20058876
S695 Phosphorylation HPRD 18669648
S715 Phosphorylation HPRD 18669648
Y719 Phosphorylation HPRD 17016520
S728 Phosphorylation HPRD 18669648, 20068231
S803 Phosphorylation HPRD 18669648
S807 Phosphorylation HPRD 20068231
S809 Phosphorylation HPRD 18669648, 20068231
S852 Phosphorylation HPRD 19651622, 18669648, 19664994, ...19664995, 20068231
S873 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
S875 Phosphorylation HPRD 17322306
S973 Phosphorylation HPRD 20068231
Y1080 Phosphorylation HPRD 17016520, 17389395
Y1127 Phosphorylation HPRD 17016520, 15951569, 17389395
T1176 Phosphorylation HPRD 15144186
Y1177 Phosphorylation HPRD 15144186
Site PTM Type PTM Enzyme Score Source PMID
S728 Phosphorylation PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T566 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T522 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
S798 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S715 Phosphorylation PhosphoSitePlus
S827 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P33151 (CDH5) S776 Q8TEW0 (PARD3) increased_association eFIP 20047332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S161 F161 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S166 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S174 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y199 C199 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S223 I223 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R294 Q294 Biomuta DOID:4159 / skin cancer [ cosmic ]
T298 P298 Biomuta DOID:1324 / lung cancer [ cosmic ]
T298 I298 Biomuta DOID:1612 / breast cancer [ cosmic ]
S370 F370 Biomuta DOID:4159 / skin cancer [ cosmic ]
S379 * Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S386 I386 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S523 F523 Biomuta DOID:4159 / skin cancer [ cosmic ]
S529 L529 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:5158 / pleural cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S533 N533 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S604 N604 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S667 C667 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
R682 K682 Biomuta DOID:4159 / skin cancer [ cosmic ]
R682 M682 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S695 R695 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S715 F715 Biomuta DOID:4159 / skin cancer [ cosmic ]
S803 L803 Biomuta DOID:4159 / skin cancer [ cosmic ]
C806 W806 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T833 A833 Biomuta DOID:1319 / brain cancer [ cosmic ]
S850 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S881 F881 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
K885 N885 Biomuta DOID:363 / uterine cancer [ icgc ]
K885 Q885 Biomuta DOID:3571 / liver cancer [ cosmic ]
S889 T889 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S962 F962 Biomuta DOID:4159 / skin cancer [ cosmic ]
S962 Y962 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4362 / cervical cancer [ icgc ]
S967 G967 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S971 F971 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1046 F1046 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S1143 G1143 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T1147 S1147 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1178 I1178 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1221 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y1221 H1221 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1239 F1239 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1239 Y1239 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1245 Y1245 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1245 F1245 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S1261 G1261 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1312 L1312 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y1321 C1321 Biomuta DOID:363 / uterine cancer [ icgc ]
S1337 A1337 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1337 F1337 Biomuta DOID:4159 / skin cancer [ cosmic ]