iPTMnet Report for Q8TEK3 (DOT1L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TEK3 / DOT1L_HUMAN
Protein Name Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene Name Name: DOT1L
Synonyms:KIAA1814,KMT4;
Organism Homo sapiens (Human)

PRO ID PR:Q8TEK3
DAG View
PRO Name histone-lysine N-methyltransferase, H3 lysine-79 specific (human)
Definition A histone-lysine N-methyltransferase, H3 lysine-79 specific that is encoded in the genome of human.
Short Label hDOT1L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TEK3 (DOT1L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation PhosphoSitePlus
Y78 Phosphorylation PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus   UniProt 23186163
S302 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
S374 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
K387 Acetylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
K397 Acetylation PhosphoSitePlus
K398 Acetylation PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus   UniProt 23186163
S458 Phosphorylation PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
S471 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T480 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K508 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
K676 Acetylation PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
T735 Phosphorylation PhosphoSitePlus
Y738 Phosphorylation PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
T751 Phosphorylation PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
Y771 Phosphorylation PhosphoSitePlus
T772 Phosphorylation IEDB   PhosphoSitePlus 32387766
S775 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S786 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y814 Phosphorylation PhosphoSitePlus
S822 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S826 Phosphorylation PhosphoSitePlus   UniProt 23186163
S834 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S846 Phosphorylation PhosphoSitePlus
Y855 Phosphorylation PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus
S858 Phosphorylation PhosphoSitePlus
S882 O-Glycosylation GlyGen 33214551, 34551297, 34019948, ...28411811, 35254053
S882 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
S899 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T900 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S902 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
T957 Phosphorylation IEDB 35494241
S982 Phosphorylation PhosphoSitePlus
T984 Phosphorylation PhosphoSitePlus   UniProt 23186163
S997 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1001 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 32357974, 18220336, ...27920218, 18669648, 27869121, 19690332, 20068231
S1007 Phosphorylation PhosphoSitePlus
S1008 Phosphorylation PhosphoSitePlus
S1009 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S1030 Phosphorylation PhosphoSitePlus
S1035 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S1039 Phosphorylation PhosphoSitePlus
S1055 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation PhosphoSitePlus
S1065 Phosphorylation PhosphoSitePlus
S1093 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1096 Phosphorylation PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1123 Phosphorylation PhosphoSitePlus
T1148 Phosphorylation IEDB 32387766
S1153 Phosphorylation PhosphoSitePlus
T1206 Phosphorylation PhosphoSitePlus
S1208 Phosphorylation PhosphoSitePlus
S1213 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T1217 Phosphorylation PhosphoSitePlus
S1246 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1256 Phosphorylation PhosphoSitePlus
S1259 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1268 Phosphorylation PhosphoSitePlus
S1349 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
K1359 Methylation PhosphoSitePlus
S1362 Phosphorylation PhosphoSitePlus
S1384 Phosphorylation PhosphoSitePlus
T1403 Phosphorylation PhosphoSitePlus
S1449 O-Glycosylation GlyGen 33214551, 34551297, 34019948, ...28411811, 35254053
S1511 O-Glycosylation GlyGen 33214551, 34551297, 34019948, ...28411811, 35254053
Site PTM Type PTM Enzyme Score Source PMID
Y78 Phosphorylation HPRD 20068231
S84 Phosphorylation HPRD 20068231
S285 Phosphorylation HPRD 20068231
T289 Phosphorylation HPRD 20068231
S297 Phosphorylation HPRD 20068231, 17924679
S302 Phosphorylation HPRD 20068231
S304 Phosphorylation HPRD 20068231
T306 Phosphorylation HPRD 20068231
S374 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995, 20068231
S448 Phosphorylation HPRD 20068231
S471 Phosphorylation HPRD 18669648, 20068231
T480 Phosphorylation HPRD 18669648, 20068231
S572 Phosphorylation HPRD 20068231
S596 Phosphorylation HPRD 18691976
Y771 Phosphorylation HPRD 20068231
S775 Phosphorylation HPRD 18669648, 20068231
S786 Phosphorylation HPRD 18669648
S822 Phosphorylation HPRD 18669648
S826 Phosphorylation HPRD 19413330
S834 Phosphorylation HPRD 19413330, 18669648, 19664994, ...20068231
S899 Phosphorylation HPRD 19651622, 18669648, 20068231
T900 Phosphorylation HPRD 18669648, 20068231
S902 Phosphorylation HPRD 19651622, 18669648, 20068231
T984 Phosphorylation HPRD 17322306
S997 Phosphorylation HPRD 20068231
S1001 Phosphorylation HPRD 18669648, 20068231
S1007 Phosphorylation HPRD 20068231
S1008 Phosphorylation HPRD 20068231
S1009 Phosphorylation HPRD 18669648, 20068231
S1035 Phosphorylation HPRD 19413330, 20068231
S1059 Phosphorylation HPRD 20068231
S1100 Phosphorylation HPRD 20068231
S1104 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
S1213 Phosphorylation HPRD 20068231
S1246 Phosphorylation HPRD 19664994
S1259 Phosphorylation HPRD 18669648
S1348 Phosphorylation HPRD 20068231
S1355 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S84 G84 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S302 L302 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T306 M306 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S458 G458 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K521 N521 Biomuta DOID:1324 / lung cancer [ cosmic ]
K521 T521 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S572 F572 Biomuta DOID:4159 / skin cancer [ cosmic ]
K601 M601 Biomuta DOID:1324 / lung cancer [ cosmic ]
K676 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S731 L731 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T735 M735 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S775 F775 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S834 C834 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S858 N858 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S982 I982 Biomuta DOID:1324 / lung cancer [ cosmic ]
S982 T982 Biomuta DOID:263 / kidney cancer [ cosmic ]
S997 L997 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1008 C1008 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1009 C1009 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1035 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1065 R1065 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1148 S1148 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1153 F1153 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1208 F1208 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1213 F1213 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1213 Y1213 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1256 L1256 Biomuta DOID:363 / uterine cancer [ icgc ]
K1359 M1359 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1362 L1362 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1511 L1511 Biomuta DOID:4606 / bile duct cancer [ cosmic ]