iPTMnet Report for Q8TDW0 (LRRC8C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDW0 / LRC8C_HUMAN
Protein Name Volume-regulated anion channel subunit LRRC8C
Gene Name Name: LRRC8C
Synonyms:AD158;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDW0
DAG View
PRO Name volume-regulated anion channel subunit LRRC8C (human)
Definition A volume-regulated anion channel subunit LRRC8C that is encoded in the genome of human.
Short Label hLRRC8C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDW0 (LRRC8C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T79 O-Glycosylation GlyGen 30459171
S87 O-Glycosylation GlyGen 30459171
S196 Phosphorylation PhosphoSitePlus
T198 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus   UniProt 23186163
K214 Ubiquitination PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K413 Acetylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
Y520 Phosphorylation PhosphoSitePlus
S543 Phosphorylation IEDB 32387766
K658 Ubiquitination PhosphoSitePlus
Y687 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 19664994
Y692 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S212 Y212 Biomuta DOID:363 / uterine cancer [ icgc ]
S215 F215 Biomuta DOID:4159 / skin cancer [ cosmic ]
K499 E499 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K499 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S543 C543 Biomuta DOID:1612 / breast cancer [ icgc ]