iPTMnet Report for Q8TDB6 (DTX3L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDB6 / DTX3L_HUMAN
Protein Name E3 ubiquitin-protein ligase DTX3L
Gene Name Name: DTX3L
Synonyms:BBAP;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDB6
DAG View
PRO Name E3 ubiquitin-protein ligase DTX3L (human)
Definition An E3 ubiquitin-protein ligase DTX3L that is encoded in the genome of human.
Short Label hDTX3L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDB6 (DTX3L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19369195
S3 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
Y16 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
T137 O-Glycosylation GlyGen 34105348
S148 O-Glycosylation GlyGen 34105348
S161 O-Glycosylation GlyGen 34105348
K164 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S204 Phosphorylation PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S221 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K232 Ubiquitination PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
K518 Acetylation PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
T526 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S535 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus   UniProt 24275569
K543 Ubiquitination PhosphoSitePlus
S545 O-Glycosylation GlyGen 34725712, 34105348, 29351928
S545 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
T567 Phosphorylation PhosphoSitePlus
C577 Methylation IEDB 31844290
S591 Phosphorylation PhosphoSitePlus
Y592 Phosphorylation PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
Y603 Phosphorylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
K653 Ubiquitination PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
K709 Ubiquitination PhosphoSitePlus
Y719 Phosphorylation PhosphoSitePlus
Y721 Phosphorylation PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 20068231
S9 Phosphorylation HPRD 18691976, 20058876, 20068231
S202 Phosphorylation HPRD 18691976, 20068231
S218 Phosphorylation HPRD 20058876
S221 Phosphorylation HPRD 18669648, 20058876
S532 Phosphorylation HPRD 20166139, 20068231, 18452278
S535 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 T3 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S9 F9 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K209 N209 Biomuta DOID:1612 / breast cancer [ cosmic ]
K209 R209 Biomuta DOID:3571 / liver cancer [ cosmic ]
S233 T233 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K356 Q356 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S514 L514 Biomuta DOID:4159 / skin cancer [ cosmic ]
K518 E518 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K518 N518 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S532 N532 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S547 C547 Biomuta DOID:3571 / liver cancer [ cosmic ]
S551 L551 Biomuta DOID:3571 / liver cancer [ cosmic ]
S591 L591 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K593 N593 Biomuta DOID:1319 / brain cancer [ cosmic ]
S698 L698 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y721 S721 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]