iPTMnet Report for Q8TD19 (NEK9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TD19 / NEK9_HUMAN
Protein Name Serine/threonine-protein kinase Nek9
Gene Name Name: NEK9
Synonyms:KIAA1995,NEK8;
Organism Homo sapiens (Human)

PRO ID PR:Q8TD19
DAG View
PRO Name serine/threonine-protein kinase Nek9 (human)
Definition A serine/threonine-protein kinase Nek9 that is encoded in the genome of human.
Short Label hNEK9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TD19 (NEK9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19369195, 22223895
S2 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19369195
C11 S-Nitrosylation dbSNO 26338901
S13 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 24275569, 19369195
S16 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19369195
S20 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
S22 Phosphorylation PhosphoSitePlus
C25 S-Nitrosylation dbSNO 26338901
S28 Phosphorylation HPRD   PhosphoSitePlus 18691976
S29 Phosphorylation Q8TD19 (NEK9) HPRD   PRO   PhosphoSitePlus   UniProt 18691976, 17192257, 24275569
S35 Phosphorylation PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus   UniProt 19369195
R60 Methylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
S76 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19369195
K81 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
T210 Phosphorylation Q8TD19 (NEK9) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11864968, 14660563, 27153399
T214 Phosphorylation PhosphoSitePlus
T254 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
K262 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
S331 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163, 20068231, ...18691976
S332 Phosphorylation Q8TD19 (NEK9) HPRD   phospho.ELM   PhosphoSitePlus 18691976, 17192257
T333 Phosphorylation Q8TD19 (NEK9) HPRD   phospho.ELM   PRO   PhosphoSitePlus   UniProt 19413330, 23186163, 18767875, ...17192257, 18669648, 19690332, 20068231
T335 Phosphorylation Q8TD19 (NEK9) HPRD   PhosphoSitePlus 17192257
Y350 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
S357 Phosphorylation HPRD   PhosphoSitePlus 18691976
T358 Phosphorylation Q8TD19 (NEK9) HPRD   phospho.ELM   PhosphoSitePlus 17192257
K361 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
C369 Methylation IEDB 31844290
K411 Ubiquitination PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
Y509 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
Y520 Phosphorylation PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
T685 Phosphorylation HPRD   PhosphoSitePlus 18691976
C696 Methylation IEDB 31844290
K731 Acetylation PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
T732 Phosphorylation PhosphoSitePlus
S735 Phosphorylation Q8TD19 (NEK9) HPRD   PhosphoSitePlus 18691976, 17192257
S741 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976
S748 Phosphorylation HPRD 18691976
S749 Phosphorylation HPRD 18691976
S750 Phosphorylation HPRD   PRO   PhosphoSitePlus 18691976
S765 Phosphorylation HPRD 18691976
S769 Phosphorylation HPRD 18691976
S793 Phosphorylation HPRD   PhosphoSitePlus 18691976
T795 Phosphorylation HPRD   PhosphoSitePlus 18691976
S801 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19369195
S805 Phosphorylation HPRD 18691976
S827 Phosphorylation HPRD   PhosphoSitePlus 18691976
S829 Phosphorylation HPRD   PhosphoSitePlus 18691976
S832 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19369195, 18691976
S836 Phosphorylation HPRD   PhosphoSitePlus 18691976
S838 Phosphorylation HPRD   PhosphoSitePlus 18691976
T842 Phosphorylation PhosphoSitePlus
Y845 Phosphorylation PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
S868 Phosphorylation Q8TD19 (NEK9) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17192257, ...19651622, 18669648, 20068231
S869 Phosphorylation HPRD   PRO   PhosphoSitePlus   UniProt 19651622, 23186163, 17081983, ...20068231
T877 O-Glycosylation GlyGen 23301498, 28657654, 34229054
T877 Phosphorylation PhosphoSitePlus
T883 Phosphorylation HPRD   PhosphoSitePlus 18691976
T886 Phosphorylation Q8TD19 (NEK9) HPRD   PhosphoSitePlus   UniProt 18691976, 17192257, 19369195
K929 Ubiquitination PhosphoSitePlus
K933 Ubiquitination PhosphoSitePlus
S944 Phosphorylation Q8TD19 (NEK9) HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 23482567, 21454704, ...19369195
K945 Ubiquitination PhosphoSitePlus
S964 Phosphorylation HPRD 18691976
S974 Phosphorylation HPRD 18691976
S978 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976


Q8TD19 (NEK9) as PTM Enzyme



Substrate Site Score Source PMID
Q8NHV4 (NEDD1) S377 neXtProt   PhosphoSitePlus 22818914
Q8TD19 (NEK9) S29 HPRD 18691976, 17192257
Q8TD19 (NEK9) T210 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14660563, 11864968
Q8TD19 (NEK9) S332 HPRD 18691976, 17192257
Q8TD19 (NEK9) T333 HPRD 19413330, 18767875, 18669648, ...17192257, 20068231
Q8TD19 (NEK9) T335 HPRD 17192257
Q8TD19 (NEK9) T358 HPRD 17192257
Q8TD19 (NEK9) S735 HPRD 18691976, 17192257
Q8TD19 (NEK9) S868 HPRD 19651622, 18691976, 18669648, ...17192257, 20068231
Q8TD19 (NEK9) T886 HPRD 18691976, 17192257
Q8TD19 (NEK9) S944 PhosphoSitePlus   Signor 21454704
Q8TDX7 (NEK7) S195 HPRD   phospho.ELM   PhosphoSitePlus   Signor 18691976, 12840024, 18452278
Q9HC98 (NEK6) S206 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 21454704, 12840024, 12101123


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048577 (hNEK9/InitMet-/Phos:2) pS29,pT210,pT333,pS750,pS869 PRO
PR:000048578 (hNEK9/InitMet-/Phos:3) pS29,pT333,pS750,pS869 PRO
PR:000048579 (hNEK9/InitMet-/Phos:4) pT333 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:4159 / skin cancer [ cosmic ]
S20 G20 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S20 N20 Biomuta DOID:1324 / lung cancer [ cosmic ]
K199 N199 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S206 F206 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S332 G332 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T358 P358 Biomuta DOID:1612 / breast cancer [ cosmic ]
S413 C413 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y520 D520 Biomuta DOID:4159 / skin cancer [ cosmic ]
S735 F735 Biomuta DOID:263 / kidney cancer [ cosmic ]
S741 F741 Biomuta DOID:4159 / skin cancer [ cosmic ]
S829 Y829 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S829 F829 Biomuta DOID:363 / uterine cancer [ icgc ]
K852 N852 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K862 T862 Biomuta DOID:4159 / skin cancer [ cosmic ]
S944 F944 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]