Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TBK2 / SETD6_HUMAN
Protein Name N-lysine methyltransferase SETD6
Gene Name Name: SETD6
Organism Homo sapiens (Human)

PRO ID PR:Q8TBK2
DAG View
PRO Name N-lysine methyltransferase SETD6 (human)
Definition An N-lysine methyltransferase SETD6 that is encoded in the genome of human.
Short Label hSETD6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TBK2 (SETD6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K39 Methylation Q8TBK2 (SETD6) UniProt 30189201
K39 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
K179 Methylation Q8TBK2 (SETD6) UniProt 30189201
K327 Ubiquitination PhosphoSitePlus
K372 Methylation Q8TBK2 (SETD6) UniProt 30189201
K385 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus


Q8TBK2 (SETD6) as PTM Enzyme



Substrate Site Score Source PMID
Q8TBK2 (SETD6) K39 UniProt 30189201
Q8TBK2 (SETD6) K179 UniProt 30189201
Q8TBK2 (SETD6) K372 UniProt 30189201


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K179 N179 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]