iPTMnet Report for Q8TB72 (PUM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TB72 / PUM2_HUMAN
Protein Name Pumilio homolog 2
Gene Name Name: PUM2
Synonyms:KIAA0235,PUMH2;
Organism Homo sapiens (Human)

PRO ID PR:Q8TB72
DAG View
PRO Name pumilio homolog 2 (human)
Definition A pumilio homolog 2 that is encoded in the genome of human.
Short Label hPUM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TB72 (PUM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T21 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus   UniProt 23186163
S75 Phosphorylation PhosphoSitePlus
S82 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S85 O-Glycosylation GlyGen 33214551, 30379171, 31492838, ...35254053, 34019948, 35289036, 28510447, 22121020, 30059200
S93 O-Glycosylation GlyGen 31373491
S93 Phosphorylation PhosphoSitePlus
Y97 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S136 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 18669648, 24275569, 20068231
T175 Phosphorylation PhosphoSitePlus
S178 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S182 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935, ...20068231
T184 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
T396 Phosphorylation PhosphoSitePlus   UniProt 24275569
S408 Phosphorylation PhosphoSitePlus
R454 Methylation PhosphoSitePlus
R462 Methylation PhosphoSitePlus
S587 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S589 O-Glycosylation GlyGen 33214551, 30379171, 31492838, ...35254053, 34019948, 35289036, 28510447, 22121020, 30059200
S589 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
Y595 Phosphorylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
Y662 Phosphorylation PhosphoSitePlus
S664 O-Glycosylation GlyGen 31492838
K672 Acetylation PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
Y673 Phosphorylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
R694 Methylation PhosphoSitePlus
Y697 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus   UniProt 23186163
K747 Ubiquitination PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
K846 Ubiquitination PhosphoSitePlus
K856 Ubiquitination PhosphoSitePlus
K948 Ubiquitination PhosphoSitePlus
K964 Ubiquitination PhosphoSitePlus
Y1003 Phosphorylation PhosphoSitePlus
T1030 Phosphorylation PhosphoSitePlus
Y1034 Phosphorylation PhosphoSitePlus
Y1036 Phosphorylation PhosphoSitePlus
K1038 Ubiquitination PhosphoSitePlus
K1043 Ubiquitination PhosphoSitePlus
K1046 Ubiquitination PhosphoSitePlus
Y1048 Phosphorylation PhosphoSitePlus
S1052 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation HPRD 20068231
S82 Phosphorylation HPRD 19651622, 18669648, 20068231
S136 Phosphorylation HPRD 17322306, 18212344, 18767875, ...19651622, 18669648, 20166139, 19415658, 20068231
S178 Phosphorylation HPRD 18669648
S182 Phosphorylation HPRD 19413330, 17322306, 18767875, ...19664994, 19664995, 19651622, 18669648, 18707149, 19415658, 20068231
T184 Phosphorylation HPRD 18669648
S587 Phosphorylation HPRD 18669648, 20068231
K818 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K762 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S178 G178 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K818 R818 Biomuta DOID:9256 / colorectal cancer [ icgc ]