iPTMnet Report Q8NHX9 TPCN2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q8NHX9 / TPC2_HUMAN
Protein Name	Two pore channel protein 2
Gene Name	Name: TPCN2 Synonyms:TPC2;
Organism	Homo sapiens (Human)

PRO ID	PR:Q8NHX9 DAG View
PRO Name	two pore channel protein 2 (human)
Definition	A two pore channel protein 2 that is encoded in the genome of human.
Short Label	hTPCN2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q8NHX9 (TPCN2) as Substrate

Q8NHX9

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T27	Phosphorylation		score1	PhosphoSitePlus
	T28	Phosphorylation		score1	PhosphoSitePlus
	Y29	Phosphorylation		score1	PhosphoSitePlus
	S31	Phosphorylation		score1	PhosphoSitePlus
	K376	Acetylation		score1	PhosphoSitePlus
	K376	Ubiquitination		score1	PhosphoSitePlus
	K398	Ubiquitination		score1	PhosphoSitePlus
	S498	Phosphorylation		score1	PhosphoSitePlus
	T571	Phosphorylation		score1	PhosphoSitePlus
	S666	Phosphorylation		score0	RLIMS-P	26838264

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
Y29	D29	Biomuta		DOID:4159 / skin cancer [ cosmic ]
K376	R376	Biomuta		DOID:1793 / pancreatic cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ icgc ]