iPTMnet Report for Q8NHV4 (NEDD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NHV4 / NEDD1_HUMAN
Protein Name Protein NEDD1
Gene Name Name: NEDD1
Organism Homo sapiens (Human)

PRO ID PR:Q8NHV4
DAG View
PRO Name protein NEDD1 (human)
Definition A protein NEDD1 that is encoded in the genome of human.
Short Label hNEDD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NHV4 (NEDD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K15 Ubiquitination PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
C213 Methylation IEDB 31844290
S215 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 33351100
S332 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S348 O-Glycosylation GlyGen 30379171, 31492838, 35138101, ...35132862, 29237092
T358 O-Glycosylation GlyGen 30379171, 31492838, 35138101, ...35132862, 29237092
K371 Ubiquitination PhosphoSitePlus
S377 Phosphorylation Q8TD19 (NEK9) neXtProt   PhosphoSitePlus   RLIMS-P 36318115, 22818914
T382 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 19509060
K385 Ubiquitination PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
S397 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 19509060
T401 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
S405 Phosphorylation O14965 (AURKA) PhosphoSitePlus   RLIMS-P   Signor 36318115, 31028180, 23273898
S411 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 36318115, 18691976, 18669648, ...23186163
S423 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S426 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 19509060
K429 Ubiquitination PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus   RLIMS-P 21690413
S468 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y487 Phosphorylation PhosphoSitePlus
S493 O-Glycosylation GlyGen 30379171, 31492838, 35138101, ...35132862, 29237092
S493 Phosphorylation PhosphoSitePlus
K494 Acetylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
T515 Phosphorylation PhosphoSitePlus
S516 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S518 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
T550 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19509060
S557 Phosphorylation PhosphoSitePlus   RLIMS-P 22595525
S558 Phosphorylation PhosphoSitePlus
T560 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus   RLIMS-P 22595525
S586 Phosphorylation PhosphoSitePlus
Y636 Phosphorylation PhosphoSitePlus
S637 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 19509060
Site PTM Type PTM Enzyme Score Source PMID
Y91 Phosphorylation HPRD 20068231
S94 Phosphorylation HPRD 20068231
S237 Phosphorylation HPRD 20068231
S238 Phosphorylation HPRD 20068231
S397 Phosphorylation HPRD 18691976
S411 Phosphorylation HPRD 18691976, 18669648
S423 Phosphorylation HPRD 18669648
S468 Phosphorylation HPRD 19651622
T515 Phosphorylation HPRD 18691976
S516 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19007248, 19664995, 18669648, 18452278, 19415658, 20068231, 19691289
S518 Phosphorylation HPRD 18691976
S574 Phosphorylation HPRD 19007248


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8NHV4 (NEDD1) S325 Q6UVJ0 (SASS6) increased_association eFIP 33351100


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T88 A88 Biomuta DOID:2021 / placenta cancer [ cosmic ]
S89 F89 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S108 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S108 L108 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S238 R238 Biomuta DOID:3571 / liver cancer [ cosmic ]
S338 F338 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S348 F348 Biomuta DOID:1319 / brain cancer [ cosmic ]
K371 I371 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S404 G404 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S423 T423 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S460 N460 Biomuta DOID:4159 / skin cancer [ cosmic ]
S468 Y468 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S518 L518 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T522 A522 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S525 Y525 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S525 A525 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S557 Y557 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S557 F557 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S566 L566 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S568 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S568 L568 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S586 F586 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y636 H636 Biomuta DOID:9256 / colorectal cancer [ cosmic ]