iPTMnet Report for Q8NFG4 (FLCN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NFG4 / FLCN_HUMAN
Protein Name Folliculin
Gene Name Name: FLCN
Synonyms:BHD;
Organism Homo sapiens (Human)

PRO ID PR:Q8NFG4
DAG View
PRO Name folliculin (human)
Definition A folliculin that is encoded in the genome of human.
Short Label hFLCN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NFG4 (FLCN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation P54646 (PRKAA2) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 21406692, 23186163, 19914239, ...23874397, 18669648, 28656962, 19695222
S68 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
S73 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 23874397, ...28656962
K100 Ubiquitination PhosphoSitePlus
S171 O-Glycosylation GlyGen 30379171, 35254053
T174 O-Glycosylation GlyGen 30379171, 35254053
K203 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S302 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19695222, 18669648, 23186163
S406 Phosphorylation PhosphoSitePlus   UniProt 25126726
R477 Methylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus   UniProt 25126726
S542 Phosphorylation PhosphoSitePlus   UniProt 25126726
S558 Phosphorylation PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation HPRD 19651622, 18669648, 19664994, ...20068231
S71 Phosphorylation HPRD 19651622
S72 Phosphorylation HPRD 19651622
S73 Phosphorylation HPRD 18669648, 19664994
S302 Phosphorylation HPRD 19413330, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation HPRD 19651622, 18669648, 19664994, ...20068231
S71 Phosphorylation HPRD 19651622
S72 Phosphorylation HPRD 19651622
S73 Phosphorylation HPRD 18669648, 19664994


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8NFG4 (FLCN) S302 P54646 (PRKAA2) increased_association eFIP 33981707


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S62 I62 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S71 F71 Biomuta DOID:1319 / brain cancer [ cosmic ]
S73 I73 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K100 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K206 N206 Biomuta DOID:1324 / lung cancer [ cosmic ]
K206 R206 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S298 N298 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S302 C302 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S406 N406 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R477 * Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S542 F542 Biomuta DOID:4159 / skin cancer [ cosmic ]
K559 N559 Biomuta DOID:1612 / breast cancer [ cosmic ]