iPTMnet Report for Q8NCM8 (DYNC2H1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NCM8 / DYHC2_HUMAN
Protein Name Cytoplasmic dynein 2 heavy chain 1
Gene Name Name: DYNC2H1
Synonyms:DHC1B,DHC2,DNCH2,DYH1B,KIAA1997;
Organism Homo sapiens (Human)

PRO ID PR:Q8NCM8
DAG View
PRO Name cytoplasmic dynein 2 heavy chain 1 (human)
Definition A cytoplasmic dynein 2 heavy chain 1 that is encoded in the genome of human.
Short Label hDYNC2H1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NCM8 (DYNC2H1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T71 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
Y424 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
Y800 Phosphorylation PhosphoSitePlus
Y973 Phosphorylation PhosphoSitePlus
K980 Ubiquitination PhosphoSitePlus
K993 Ubiquitination PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
K1087 Ubiquitination PhosphoSitePlus
S1177 Phosphorylation PhosphoSitePlus
Y1281 Phosphorylation PhosphoSitePlus
S1286 Phosphorylation PhosphoSitePlus
K1296 Ubiquitination PhosphoSitePlus
R1306 Methylation PhosphoSitePlus
S1311 Phosphorylation PhosphoSitePlus
K1348 Ubiquitination PhosphoSitePlus
T1380 Phosphorylation PhosphoSitePlus
K1383 Acetylation PhosphoSitePlus
S1414 Phosphorylation PhosphoSitePlus
K1487 Ubiquitination PhosphoSitePlus
S1636 Phosphorylation PhosphoSitePlus
Y1688 Phosphorylation PhosphoSitePlus
K1803 Ubiquitination PhosphoSitePlus
T1911 Phosphorylation PhosphoSitePlus
T1916 Phosphorylation PhosphoSitePlus
Y1936 Phosphorylation PhosphoSitePlus
S1981 Phosphorylation PhosphoSitePlus
Y2230 Phosphorylation PhosphoSitePlus
Y2231 Phosphorylation PhosphoSitePlus
Y2241 Phosphorylation PhosphoSitePlus
Y2346 Phosphorylation PhosphoSitePlus
Y2509 Phosphorylation PhosphoSitePlus
Y2522 Phosphorylation PhosphoSitePlus
K2608 Ubiquitination PhosphoSitePlus
K2688 Ubiquitination PhosphoSitePlus
K2818 Ubiquitination PhosphoSitePlus
K2832 Ubiquitination PhosphoSitePlus
K2836 Ubiquitination PhosphoSitePlus
K2917 Ubiquitination PhosphoSitePlus
K2966 Methylation PhosphoSitePlus
K2996 Ubiquitination PhosphoSitePlus
K3223 Ubiquitination PhosphoSitePlus
K3231 Ubiquitination PhosphoSitePlus
K3237 Ubiquitination PhosphoSitePlus
T3246 Phosphorylation PhosphoSitePlus
S3255 Phosphorylation PhosphoSitePlus
R3342 Methylation PhosphoSitePlus
K3465 Ubiquitination PhosphoSitePlus
T3650 Phosphorylation PhosphoSitePlus
K3711 Ubiquitination PhosphoSitePlus
Y3900 Phosphorylation PhosphoSitePlus
K4030 Ubiquitination PhosphoSitePlus
K4205 Ubiquitination PhosphoSitePlus
K4212 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1177 Phosphorylation HPRD 19664994
Y1281 Phosphorylation HPRD 18452278
S1286 Phosphorylation HPRD 18452278
T1911 Phosphorylation HPRD 18452278
T1916 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T157 K157 Biomuta DOID:184 / bone cancer [ cosmic ]
S283 R283 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S289 L289 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S351 N351 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T359 S359 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T432 P432 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y800 H800 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1286 R1286 Biomuta DOID:363 / uterine cancer [ icgc ]
K1296 T1296 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1348 N1348 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1414 L1414 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1688 C1688 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1688 N1688 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y2231 C2231 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y2241 H2241 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K2688 N2688 Biomuta DOID:1319 / brain cancer [ cosmic ]
K2836 T2836 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K3231 R3231 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S3255 R3255 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R3342 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:3953 / adrenal gland cancer [ cosmic ]
R3342 G3342 Biomuta DOID:1324 / lung cancer [ cosmic ]
R3342 Q3342 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y3900 C3900 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y3900 H3900 Biomuta DOID:9256 / colorectal cancer [ cosmic ]