iPTMnet Report for Q8NCD3 (HJURP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NCD3 / HJURP_HUMAN
Protein Name Holliday junction recognition protein
Gene Name Name: HJURP
Synonyms:FAKTS,FLEG1;
Organism Homo sapiens (Human)

PRO ID PR:Q8NCD3
DAG View
PRO Name Holliday junction recognition protein (human)
Definition A Holliday junction recognition protein that is encoded in the genome of human.
Short Label hHJURP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NCD3 (HJURP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K21 Ubiquitination PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
T122 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S123 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S128 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S140 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
Y163 Phosphorylation PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S185 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
Y193 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus   UniProt 23186163
K207 Ubiquitination PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus   UniProt 23186163
N231 N-Glycosylation GlyGen 29671580
K278 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
T380 O-Glycosylation GlyGen 30379171
T380 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
K408 Sumoylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
S412 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
K415 Ubiquitination PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
Y445 Phosphorylation PhosphoSitePlus
S448 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S473 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 18220336, 18669648, 19369195, 19690332, 20068231
T482 Phosphorylation PhosphoSitePlus
S486 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   UniProt 17256767, 23186163
S489 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
K495 Methylation PhosphoSitePlus
K495 Sumoylation PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus   UniProt 23186163
K506 Methylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
K517 Sumoylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
S557 Phosphorylation IEDB   PhosphoSitePlus 32387766
S559 Phosphorylation PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
K581 Sumoylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus   UniProt 20068231
T600 Phosphorylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
S642 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
K648 Sumoylation PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
T654 Phosphorylation PhosphoSitePlus
C663 Methylation IEDB 31844290
K681 Ubiquitination PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
K735 Sumoylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
K742 Sumoylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T122 Phosphorylation HPRD 18669648
S123 Phosphorylation HPRD 18669648
S128 Phosphorylation HPRD 18669648
S140 Phosphorylation HPRD 18669648, 18452278
S185 Phosphorylation HPRD 19413330
N231 N-Glycosylation PRO 29671580
S303 Phosphorylation HPRD 18452278
S412 Phosphorylation HPRD 15302935, 18669648, 19664994, ...19664995, 20068231
S448 Phosphorylation HPRD 18669648, 19664994
S473 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20058876, 19664994, 19664995, 18669648, 18767875, 20068231
T482 Phosphorylation HPRD 20068231
S486 Phosphorylation HPRD 18691976, 20068231
S490 Phosphorylation HPRD 20068231
S595 Phosphorylation HPRD 20068231
S642 Phosphorylation HPRD 18691976, 18669648, 19664995


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P49450 (CENPA) S68 Q8NCD3 (HJURP) unknown eFIP 29479426


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K21 E21 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S116 G116 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y163 N163 Biomuta DOID:4159 / skin cancer [ cosmic ]
T178 S178 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K375 N375 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S412 Y412 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T482 P482 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T482 I482 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S508 Y508 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T600 K600 Biomuta DOID:3571 / liver cancer [ cosmic ]
K611 R611 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S641 P641 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S642 P642 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S649 I649 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]