iPTMnet Report for Q8NC54 (KCT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NC54 / KCT2_HUMAN
Protein Name Keratinocyte-associated transmembrane protein 2 precursor
Gene Name Name: KCT2
Synonyms:C5orf15;ORFNames:HTGN29;
Organism Homo sapiens (Human)

PRO ID PR:Q8NC54
DAG View
PRO Name keratinocyte-associated transmembrane protein 2 (human)
Definition A keratinocyte-associated transmembrane protein 2 that is encoded in the genome of human.
Short Label hKCT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NC54 (KCT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T51 O-Glycosylation GlyGen 25813380
S53 O-Glycosylation GlyGen 25813380
S55 O-Glycosylation GlyGen 25813380
S165 Phosphorylation HPRD 20187088
T168 Phosphorylation HPRD 20187088
Y175 Phosphorylation PhosphoSitePlus
S229 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
C237 Methylation IEDB 31844290
K239 Ubiquitination PhosphoSitePlus
T240 Phosphorylation HPRD   PhosphoSitePlus 19651622
Y243 Phosphorylation HPRD   PhosphoSitePlus 19651622
S256 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
K258 Ubiquitination PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S165 F165 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K239 N239 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y243 H243 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K258 M258 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y263 F263 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]