iPTMnet Report for Q8N6M0 (OTUD6B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N6M0 / OTU6B_HUMAN
Protein Name Deubiquitinase OTUD6B
Gene Name Name: OTUD6B
Synonyms:DUBA5;ORFNames:CGI-77;
Organism Homo sapiens (Human)

PRO ID PR:Q8N6M0
DAG View
PRO Name deubiquitinase OTUD6B (human)
Definition A deubiquitinase OTUD6B that is encoded in the genome of human.
Short Label hOTUD6B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N6M0 (OTUD6B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
K24 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K57 Acetylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K29 N29 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K34 E34 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K34 N34 Biomuta DOID:363 / uterine cancer [ cosmic ]
K57 T57 Biomuta DOID:263 / kidney cancer [ cosmic ]
K71 N71 Biomuta DOID:363 / uterine cancer [ cosmic ]
T183 S183 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T183 I183 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y272 H272 Biomuta DOID:9256 / colorectal cancer [ cosmic ]