iPTMnet Report for Q8N6H7 (ARFGAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N6H7 / ARFG2_HUMAN
Protein Name ADP-ribosylation factor GTPase-activating protein 2
Gene Name Name: ARFGAP2
Synonyms:ZNF289;ORFNames:Nbla10535;
Organism Homo sapiens (Human)

PRO ID PR:Q8N6H7
DAG View
PRO Name ADP-ribosylation factor GTPase-activating protein 2 (human)
Definition An ADP-ribosylation factor GTPase-activating protein 2 that is encoded in the genome of human.
Short Label hARFGAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N6H7 (ARFGAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K7 Ubiquitination PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
C97 Methylation IEDB 32357974
K105 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus   UniProt 24275569
S146 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 19690332, 20068231
S180 Phosphorylation phospho.ELM 18669648
S201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
K209 Ubiquitination PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
K223 Acetylation PhosphoSitePlus
K228 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus   UniProt 23186163
S238 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus   UniProt 23186163
S242 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus   UniProt 23186163
S314 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus   UniProt 24275569
K336 Ubiquitination PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus   UniProt 23186163
T350 Phosphorylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus   UniProt 23186163
S368 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18669648, ...24275569, 19690332, 20068231
S371 Phosphorylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
S432 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S433 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y445 Phosphorylation PhosphoSitePlus
S498 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S513 Phosphorylation PhosphoSitePlus   UniProt 23186163
S520 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD 20068231
T131 Phosphorylation HPRD 17081983
S139 Phosphorylation HPRD 20230923
S140 Phosphorylation HPRD 20166139, 17081983, 20230923
S146 Phosphorylation HPRD 19413330, 18691976, 17081983, ...18452278, 19651622, 18669648, 20166139, 20068231
S180 Phosphorylation HPRD 18669648
S201 Phosphorylation HPRD 18669648
S368 Phosphorylation HPRD 18691976, 18212344, 19651622, ...18669648, 20166139, 20068231
S432 Phosphorylation HPRD 19413330, 18212344, 19664995, ...19651622, 18669648, 20068231
S433 Phosphorylation HPRD 20068231
S498 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T8 I8 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S140 N140 Biomuta DOID:363 / uterine cancer [ icgc ]
S146 F146 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S237 N237 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S238 N238 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S242 T242 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S337 Y337 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S340 L340 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K357 N357 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K357 R357 Biomuta DOID:1324 / lung cancer [ cosmic ]
S364 F364 Biomuta DOID:4159 / skin cancer [ cosmic ]
S364 A364 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K387 N387 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S413 G413 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K429 R429 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S432 L432 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S513 F513 Biomuta DOID:4159 / skin cancer [ cosmic ]