iPTMnet Report for Q8N196 (SIX5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N196 / SIX5_HUMAN
Protein Name Homeobox protein SIX5
Gene Name Name: SIX5
Synonyms:DMAHP;
Organism Homo sapiens (Human)

PRO ID PR:Q8N196
DAG View
PRO Name homeobox protein SIX5 (human)
Definition A homeobox protein SIX5 that is encoded in the genome of human.
Short Label hSIX5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N196 (SIX5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
R121 Methylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
R168 Methylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
T380 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S66 F66 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R121 S121 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R121 H121 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T380 A380 Biomuta DOID:10534 / stomach cancer [ cosmic ]