iPTMnet Report for Q8IZW8 (TNS4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZW8 / TENS4_HUMAN
Protein Name Tensin-4 precursor
Gene Name Name: TNS4
Synonyms:CTEN;ORFNames:PP14434;
Organism Homo sapiens (Human)

PRO ID PR:Q8IZW8
DAG View
PRO Name tensin-4 (human)
Definition A tensin-4 that is encoded in the genome of human.
Short Label hTNS4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZW8 (TNS4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y42 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
S82 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976
Y97 Phosphorylation PhosphoSitePlus
S136 Phosphorylation HPRD 20068231
K139 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
T154 O-Glycosylation GlyGen 31492838, 35254053
S168 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
R209 Methylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S241 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231
S242 Phosphorylation HPRD 18691976, 20068231
S248 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
S253 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231
S269 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
S350 Phosphorylation HPRD   PhosphoSitePlus 18691976
S404 Phosphorylation HPRD   PhosphoSitePlus 18691976
T412 O-Glycosylation GlyGen 31492838, 35254053
S416 Phosphorylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
Y448 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
S571 Phosphorylation HPRD   PhosphoSitePlus 18691976
S574 Phosphorylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
Y644 Phosphorylation PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus
Y664 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S82 F82 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S168 C168 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S171 F171 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S204 C204 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S228 F228 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S230 R230 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S230 N230 Biomuta DOID:1319 / brain cancer [ cosmic ]
S230 C230 Biomuta DOID:1319 / brain cancer [ cosmic ]
S232 L232 Biomuta [ cosmic ]
S241 L241 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:184 / bone cancer [ cosmic ]
S253 F253 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S269 N269 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S350 C350 Biomuta DOID:1319 / brain cancer [ cosmic ]
S404 F404 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T412 A412 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T412 P412 Biomuta DOID:1612 / breast cancer [ cosmic ]
S416 R416 Biomuta DOID:363 / uterine cancer [ cosmic ]
S416 N416 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K440 T440 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S477 F477 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S477 C477 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K488 N488 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K518 R518 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K518 T518 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S574 Y574 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K577 T577 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T647 I647 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]