iPTMnet Report for Q8IZ21 (PHACTR4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZ21 / PHAR4_HUMAN
Protein Name Phosphatase and actin regulator 4
Gene Name Name: PHACTR4
ORFNames:PRO2963;
Organism Homo sapiens (Human)

PRO ID PR:Q8IZ21
DAG View
PRO Name phosphatase and actin regulator 4 (human)
Definition A phosphatase and actin regulator 4 that is encoded in the genome of human.
Short Label hPHACTR4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZ21 (PHACTR4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T28 Phosphorylation PhosphoSitePlus
T31 Phosphorylation PhosphoSitePlus
K32 Methylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K42 Acetylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
S70 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S99 Phosphorylation phospho.ELM 15302935
T109 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
S118 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S131 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S147 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
T148 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S150 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S176 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
T190 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 31373491
S191 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 31373491
T195 Phosphorylation PhosphoSitePlus
S201 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 32938750, 34019948, 28657654, 30059200, 35132862, 31492838, 32119511, 30620550, 31373491
S201 Phosphorylation PhosphoSitePlus
T202 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 32938750, 34019948, 28657654, 30059200, 35132862, 31492838, 32119511, 30620550, 31373491
T202 Phosphorylation PhosphoSitePlus
S203 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 32938750, 34019948, 28657654, 30059200, 35132862, 31492838, 32119511, 30620550, 31373491
T205 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 31373491
T211 O-Glycosylation GlyGen 32938750
S216 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 31373491
S216 Phosphorylation PhosphoSitePlus
T220 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 31373491
S224 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
T233 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 31373491
S240 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 31373491
T244 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30059200, 28657654, 30620550, 35132862, 31492838, 32119511, 35254053, 31373491
S270 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus   UniProt 23186163
S302 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S342 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S344 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T349 Phosphorylation PhosphoSitePlus
T358 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S410 Phosphorylation PhosphoSitePlus
S427 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
T432 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S438 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus   UniProt 23186163
S451 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
T468 Phosphorylation PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
Y534 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus   UniProt 24275569
S565 Phosphorylation PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
T584 Phosphorylation PhosphoSitePlus
S590 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T594 Phosphorylation PhosphoSitePlus
T624 Phosphorylation PhosphoSitePlus
S628 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
T632 Phosphorylation PhosphoSitePlus
Y647 Phosphorylation PhosphoSitePlus
T651 Phosphorylation PhosphoSitePlus
Y656 Phosphorylation PhosphoSitePlus
T665 Phosphorylation PhosphoSitePlus
T668 Phosphorylation PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
Y699 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S116 Phosphorylation HPRD 19651622
S117 Phosphorylation HPRD 18491316
S118 Phosphorylation HPRD 19413330, 18491316, 18767875, ...20058876, 19664995, 19651622, 18669648, 18707149, 19415658, 20068231
S131 Phosphorylation HPRD 19651622, 18669648
S147 Phosphorylation HPRD 17525332
T148 Phosphorylation HPRD 18669648
S150 Phosphorylation HPRD 17525332
S176 Phosphorylation HPRD 19651622, 19664995, 20068231
S291 Phosphorylation HPRD 19651622, 20068231
S302 Phosphorylation HPRD 20068231
S342 Phosphorylation HPRD 19651622, 18669648
S344 Phosphorylation HPRD 19651622, 18669648
T349 Phosphorylation HPRD 19651622
T358 Phosphorylation HPRD 19651622, 18669648
S427 Phosphorylation HPRD 18669648, 20068231
T432 Phosphorylation HPRD 18669648
S464 Phosphorylation HPRD 19651622, 20068231
S514 Phosphorylation HPRD 19651622
S516 Phosphorylation HPRD 19651622
S518 Phosphorylation HPRD 19651622
T584 Phosphorylation HPRD 18212344
S590 Phosphorylation HPRD 20068231
T594 Phosphorylation HPRD 17081983
S628 Phosphorylation HPRD 17081983, 18767875, 19651622, ...18669648, 18707149, 20068231
T632 Phosphorylation HPRD 19651622, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S126 Phosphorylation HPRD 19651622
S127 Phosphorylation HPRD 18491316
S128 Phosphorylation HPRD 19413330, 18491316, 20058876, ...18767875, 15302935, 19664995, 19651622, 18669648, 18707149, 19415658, 20068231
S141 Phosphorylation HPRD 19651622, 18669648
S157 Phosphorylation HPRD 17525332
T158 Phosphorylation HPRD 18669648
S160 Phosphorylation HPRD 17525332
S186 Phosphorylation HPRD 19651622, 19664995, 20068231
S301 Phosphorylation HPRD 19651622, 20068231
S312 Phosphorylation HPRD 20068231
S352 Phosphorylation HPRD 19651622, 18669648
S354 Phosphorylation HPRD 19651622, 18669648
T359 Phosphorylation HPRD 19651622
T368 Phosphorylation HPRD 19651622, 18669648
S437 Phosphorylation HPRD 18669648, 20068231
T442 Phosphorylation HPRD 18669648
S474 Phosphorylation HPRD 19651622, 20068231
S524 Phosphorylation HPRD 19651622
S526 Phosphorylation HPRD 19651622
S528 Phosphorylation HPRD 19651622
T594 Phosphorylation HPRD 18212344
S600 Phosphorylation HPRD 20068231
T604 Phosphorylation HPRD 17081983
S638 Phosphorylation HPRD 17081983, 18767875, 19651622, ...18669648, 18707149, 20068231
T642 Phosphorylation HPRD 19651622, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T28 I28 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S62 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S70 P70 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S70 C70 Biomuta DOID:1324 / lung cancer [ cosmic ]
S99 N99 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S116 L116 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
S126 L126 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
S150 I150 Biomuta DOID:3571 / liver cancer [ cosmic ]
S160 I160 Biomuta DOID:3571 / liver cancer [ cosmic ]
S191 F191 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S201 C201 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S270 N270 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S288 L288 Biomuta DOID:4159 / skin cancer [ cosmic ]
S304 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S332 L332 Biomuta DOID:184 / bone cancer [ cosmic ]
S332 W332 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S342 Y342 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S352 Y352 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T358 I358 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T368 I368 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S410 F410 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T432 I432 Biomuta DOID:4159 / skin cancer [ cosmic ]
T442 I442 Biomuta DOID:4159 / skin cancer [ cosmic ]
S443 L443 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S451 R451 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S451 N451 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S453 Y453 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T462 I462 Biomuta DOID:1324 / lung cancer [ cosmic ]
T468 I468 Biomuta DOID:363 / uterine cancer [ icgc ]
S514 N514 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S524 N524 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y647 H647 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y656 C656 Biomuta DOID:184 / bone cancer [ cosmic ]
K672 N672 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y699 * Biomuta DOID:363 / uterine cancer [ cosmic ]