iPTMnet Report for Q8IX90 (SKA3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IX90 / SKA3_HUMAN
Protein Name Spindle and kinetochore-associated protein 3
Gene Name Name: SKA3
Synonyms:C13orf3,RAMA1;
Organism Homo sapiens (Human)

PRO ID PR:Q8IX90
DAG View
PRO Name spindle and kinetochore-associated protein 3 (human)
Definition A spindle and kinetochore-associated protein RAMA1 that is encoded in the genome of human.
Short Label hSKA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IX90 (SKA3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Ubiquitination PhosphoSitePlus
S34 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...16565220
Y39 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
S103 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K108 Ubiquitination PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S119 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S124 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus   UniProt 23186163
S146 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
S152 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 18220336
S155 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...15144186, 18669648, 19690332, 20068231
S159 Phosphorylation Q96GD4 (AURKB) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22371557, 23186163, 16565220
K183 Ubiquitination PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus   RLIMS-P 19387489
T193 Phosphorylation RLIMS-P 19387489
K194 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
T217 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y228 Phosphorylation PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
T265 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 16565220
S267 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...16565220
K275 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
Y280 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
T281 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
T291 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K295 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
Y310 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
S317 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S318 Phosphorylation PhosphoSitePlus   UniProt 19690332
S319 Phosphorylation PhosphoSitePlus
S346 Phosphorylation IEDB 25880248
T358 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
T360 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 33106477, 16565220
K366 Ubiquitination PhosphoSitePlus
T384 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K399 Ubiquitination PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S34 Phosphorylation HPRD 18669648, 20068231, 16565220
S87 Phosphorylation HPRD 20068231
S103 Phosphorylation HPRD 18669648
S119 Phosphorylation HPRD 18669648
S152 Phosphorylation HPRD 19651622, 20068231
S155 Phosphorylation HPRD 20230923, 20058876, 19664994, ...19007248, 15144186, 19664995, 19651622, 18669648, 16565220, 20068231
S159 Phosphorylation HPRD 16565220, 20068231, 20230923
T190 Phosphorylation HPRD 19664994, 19007248
S196 Phosphorylation HPRD 20068231
T217 Phosphorylation HPRD 18669648, 19007248
T265 Phosphorylation HPRD 18669648, 20068231, 16565220
S267 Phosphorylation HPRD 18669648, 20068231, 16565220
S276 Phosphorylation HPRD 19007248
Y280 Phosphorylation HPRD 15592455
S283 Phosphorylation HPRD 16565220
T291 Phosphorylation HPRD 16565220
S302 Phosphorylation HPRD 18452278
S307 Phosphorylation HPRD 18452278
S313 Phosphorylation HPRD 18452278
T315 Phosphorylation HPRD 19007248
S317 Phosphorylation HPRD 18669648
S318 Phosphorylation HPRD 19007248, 19691289
T358 Phosphorylation HPRD 16565220
T360 Phosphorylation HPRD 16565220
S380 Phosphorylation HPRD 20068231
T384 Phosphorylation HPRD 18669648, 19007248, 20068231
S394 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K366 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8IX90 (SKA3) T360 P53350 (PLK1) unknown eFIP 33106477


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y39 H39 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
K108 T108 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K108 E108 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S124 P124 Biomuta DOID:263 / kidney cancer [ cosmic ]
T132 S132 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S139 C139 Biomuta DOID:1612 / breast cancer [ cosmic ]
K151 N151 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S152 F152 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ icgc ]
S152 C152 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S196 P196 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y228 F228 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y236 C236 Biomuta DOID:363 / uterine cancer [ icgc ]
S267 G267 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y280 F280 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T281 A281 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T281 I281 Biomuta DOID:3571 / liver cancer [ cosmic ]
T291 I291 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
S302 N302 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S313 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S318 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S346 L346 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T358 I358 Biomuta DOID:3571 / liver cancer [ cosmic ]
K366 E366 Biomuta DOID:4159 / skin cancer [ cosmic ]
S380 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S394 G394 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]