iPTMnet Report for Q8IWZ8 (SUGP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWZ8 / SUGP1_HUMAN
Protein Name SURP and G-patch domain-containing protein 1
Gene Name Name: SUGP1
Synonyms:SF4;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWZ8
DAG View
PRO Name SURP and G-patch domain-containing protein 1 (human)
Definition A splicing factor 4 that is encoded in the genome of human.
Short Label hSUGP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWZ8 (SUGP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K27 Acetylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S102 O-Glycosylation GlyGen 34846842
T107 O-Glycosylation GlyGen 23301498, 29351928, 35138101, ...30379171, 32574038, 34019948, 35254053, 35132862, 31492838, 32119511, 35289036, 30620550, 29237092
S108 O-Glycosylation GlyGen 23301498, 34846842, 29351928, ...35138101, 30379171, 32574038, 32938750, 34019948, 35254053, 35132862, 31492838, 32119511, 35289036, 30620550, 29237092
S111 O-Glycosylation GlyGen 23301498, 34846842, 29351928, ...35138101, 30379171, 32574038, 34019948, 35254053, 35132862, 31492838, 32119511, 35289036, 30620550, 31373491, 29237092
S111 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
T116 O-Glycosylation GlyGen 23301498, 29351928, 35138101, ...30379171, 32574038, 34019948, 35254053, 35132862, 31492838, 32119511, 35289036, 30620550, 29237092
T116 Phosphorylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
S120 O-Glycosylation GlyGen 34846842
K123 Acetylation PhosphoSitePlus
K123 Methylation PhosphoSitePlus
S125 O-Glycosylation GlyGen 23301498, 29351928, 35138101, ...30379171, 32574038, 34019948, 35254053, 35132862, 31492838, 32119511, 35289036, 30620550, 29237092
T132 Phosphorylation PhosphoSitePlus   UniProt 23186163
S145 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus   UniProt 23186163
S326 Phosphorylation PhosphoSitePlus   UniProt 23186163
K335 Methylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S409 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S411 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S414 Phosphorylation PhosphoSitePlus   UniProt 19690332
K419 Ubiquitination PhosphoSitePlus
K427 Sumoylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
Y483 Phosphorylation PhosphoSitePlus
S485 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S491 Phosphorylation PhosphoSitePlus
T516 Phosphorylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K542 Methylation PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
T561 Phosphorylation PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
R641 Methylation PhosphoSitePlus
R642 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T118 Phosphorylation HPRD 19413330
S409 Phosphorylation HPRD 19651622, 18669648, 20068231
S411 Phosphorylation HPRD 19651622, 18669648, 20068231
Y483 Phosphorylation HPRD 18691976, 17081983
S485 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S108 N108 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y172 C172 Biomuta DOID:3571 / liver cancer [ cosmic ]
S256 L256 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S411 L411 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K542 N542 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K589 N589 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R642 W642 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]