iPTMnet Report for Q8IWV7 (UBR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWV7 / UBR1_HUMAN
Protein Name E3 ubiquitin-protein ligase UBR1
Gene Name Name: UBR1
Organism Homo sapiens (Human)

PRO ID PR:Q8IWV7
DAG View
PRO Name E3 ubiquitin-protein ligase UBR1 (human)
Definition An E3 ubiquitin-protein ligase UBR1 that is encoded in the genome of human.
Short Label hUBR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWV7 (UBR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19369195
S15 Phosphorylation PhosphoSitePlus
T21 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 23186163, 18691976, ...15302935, 24275569, 19690332
K91 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
C477 Methylation IEDB 31844290
S575 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
T614 Phosphorylation PhosphoSitePlus
Y688 Phosphorylation PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
K788 Ubiquitination PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K824 Ubiquitination PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
K859 Ubiquitination PhosphoSitePlus
T901 Phosphorylation PhosphoSitePlus
K944 Ubiquitination PhosphoSitePlus
K991 Ubiquitination PhosphoSitePlus
T999 O-Glycosylation GlyGen 28510447, 28657654
K1032 Ubiquitination PhosphoSitePlus
K1042 Ubiquitination PhosphoSitePlus
K1049 Ubiquitination PhosphoSitePlus
Y1052 Phosphorylation PhosphoSitePlus
K1085 Ubiquitination PhosphoSitePlus
K1093 Ubiquitination PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
S1179 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
Y1302 Phosphorylation PhosphoSitePlus
S1593 Phosphorylation PhosphoSitePlus
K1681 Ubiquitination PhosphoSitePlus
K1703 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T21 Phosphorylation HPRD 18691976, 20068231
S1179 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K458 T458 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K468 R468 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S582 R582 Biomuta DOID:1612 / breast cancer [ cosmic ]
S582 I582 Biomuta DOID:1324 / lung cancer [ cosmic ]
K806 R806 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K812 T812 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K859 E859 Biomuta DOID:1324 / lung cancer [ cosmic ]
K944 N944 Biomuta DOID:263 / kidney cancer [ cosmic ]
K944 R944 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T999 I999 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K1032 T1032 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y1052 F1052 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1052 H1052 Biomuta DOID:9256 / colorectal cancer [ cosmic ]