iPTMnet Report for Q8IWV7 (UBR1)
Protein Information
UniProt AC / UniProt ID | Q8IWV7 / UBR1_HUMAN |
Protein Name | E3 ubiquitin-protein ligase UBR1 |
Gene Name | Name: UBR1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q8IWV7 |
PRO Name | E3 ubiquitin-protein ligase UBR1 (human) |
Definition | An E3 ubiquitin-protein ligase UBR1 that is encoded in the genome of human. |
Short Label | hUBR1 |
Category | organism-gene |
Q8IWV7 (UBR1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19369195 | ||
S15 | Phosphorylation | score1 | PhosphoSitePlus | |||
T21 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 19369195, 23186163, 18691976, ... | ||
K91 | Ubiquitination | score1 | PhosphoSitePlus | |||
K104 | Ubiquitination | score1 | PhosphoSitePlus | |||
K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
K272 | Ubiquitination | score1 | PhosphoSitePlus | |||
K283 | Ubiquitination | score1 | PhosphoSitePlus | |||
K397 | Ubiquitination | score1 | PhosphoSitePlus | |||
T423 | Phosphorylation | score1 | PhosphoSitePlus | |||
T426 | Phosphorylation | score1 | PhosphoSitePlus | |||
K458 | Ubiquitination | score1 | PhosphoSitePlus | |||
K468 | Ubiquitination | score1 | PhosphoSitePlus | |||
C477 | Methylation | score1 | IEDB | 31844290 | ||
S575 | Phosphorylation | score1 | PhosphoSitePlus | |||
S580 | Phosphorylation | score1 | PhosphoSitePlus | |||
S582 | Phosphorylation | score1 | PhosphoSitePlus | |||
K596 | Ubiquitination | score1 | PhosphoSitePlus | |||
T614 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y688 | Phosphorylation | score1 | PhosphoSitePlus | |||
K706 | Ubiquitination | score1 | PhosphoSitePlus | |||
K728 | Ubiquitination | score1 | PhosphoSitePlus | |||
K764 | Ubiquitination | score1 | PhosphoSitePlus | |||
K788 | Ubiquitination | score1 | PhosphoSitePlus | |||
K806 | Ubiquitination | score1 | PhosphoSitePlus | |||
K812 | Ubiquitination | score1 | PhosphoSitePlus | |||
K824 | Ubiquitination | score1 | PhosphoSitePlus | |||
K855 | Ubiquitination | score1 | PhosphoSitePlus | |||
K859 | Ubiquitination | score1 | PhosphoSitePlus | |||
T901 | Phosphorylation | score1 | PhosphoSitePlus | |||
K944 | Ubiquitination | score1 | PhosphoSitePlus | |||
K991 | Ubiquitination | score1 | PhosphoSitePlus | |||
T999 | O-Glycosylation | score1 | GlyGen | 28510447, 28657654 | ||
K1032 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1042 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1049 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y1052 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1085 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1093 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1122 | Ubiquitination | score1 | PhosphoSitePlus | |||
S1179 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 17525332 | ||
Y1302 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1593 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1681 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1703 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K458 | T458 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K468 | R468 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S582 | R582 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S582 | I582 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K806 | R806 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K812 | T812 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
K859 | E859 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K944 | N944 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
K944 | R944 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
T999 | I999 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
K1032 | T1032 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
Y1052 | F1052 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
Y1052 | H1052 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |